All Phenotypes Nr3c1<tm1Dage> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr3c1^tm1Dage/Nr3c1^tm1Dage	involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL	MGI:3843005
ht2	Nr3c1^tm1Dage/Nr3c1⁺	involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL	MGI:3843006

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced adrenal weight in Nr3c1^tm1Dage/Nr3c1^tm1Dage and Nr3c1^tm1Dage/Nr3c1⁺ mice

homeostasis/metabolism

decreased circulating testosterone level ( J:147914 )

• mice treated with dexamethasone exhibit reduced testosterone levels compared to in similarly treated wild-type mice

decreased circulating corticosterone level ( J:147914 )

• at morning nadir, evening diurnal peak, during food deprivation, and following injection with ACTH compared to in wild-type mice

decreased circulating adrenocorticotropin level ( J:147914 )

• at morning nadir, evening diurnal peak, and during stress compared to in wild-type mice

abnormal physiological response to xenobiotic ( J:147914 )

• low dose dexamethasone results in increased mean arterial blood pressure unlike in wild-type mice that is more pronounced during the daytime phase

• mice treated with dexamethasone exhibit reduced testosterone levels compared to in similarly treated wild-type mice

endocrine/exocrine glands

decreased adrenal gland zona fasciculata size ( J:147914 )

• reduced in size

thin adrenal cortex ( J:147914 )

small adrenal glands ( J:147914 )

• 55% of wild-type

immune system

decreased B cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

decreased macrophage cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

cardiovascular system

increased mean systemic arterial blood pressure ( J:147914 )

• low dose dexamethasone results in increased mean arterial blood pressure unlike in wild-type mice that is more pronounced during the daytime phase

hematopoietic system

decreased B cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

decreased macrophage cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

Allelic Composition	Nr3c1^tm1Dage/Nr3c1⁺
Genetic Background	involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1^tm1Dage mutation (0 available); any Nr3c1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced adrenal weight in Nr3c1^tm1Dage/Nr3c1^tm1Dage and Nr3c1^tm1Dage/Nr3c1⁺ mice

homeostasis/metabolism

decreased circulating testosterone level ( J:147914 )

• mice treated with dexamethasone exhibit reduced testosterone levels compared to in similarly treated wild-type mice

decreased circulating corticosterone level ( J:147914 )

• at morning nadir, evening diurnal peak, during food deprivation, and following injection with ACTH compared to in wild-type mice

decreased circulating adrenocorticotropin level ( J:147914 )

• at morning nadir, evening diurnal peak, and during stress compared to in wild-type mice

abnormal physiological response to xenobiotic ( J:147914 )

• low dose dexamethasone results in increased mean arterial blood pressure unlike in wild-type mice that is more pronounced during the daytime phase

• mice treated with dexamethasone exhibit reduced testosterone levels compared to in similarly treated wild-type mice

endocrine/exocrine glands

decreased adrenal gland zona fasciculata size ( J:147914 )

• reduced in size

thin adrenal cortex ( J:147914 )

small adrenal glands ( J:147914 )

• 55% of wild-type

immune system

decreased B cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

cardiovascular system

increased mean systemic arterial blood pressure ( J:147914 )

• low dose dexamethasone results in increased mean arterial blood pressure unlike in wild-type mice that is more pronounced during the daytime phase

hematopoietic system

decreased B cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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