All Phenotypes Zc3h12a<tm1Aki> MGI Mouse

premature death ( J:147868 )

• mice die spontaneously at 12 weeks of age

enlarged spleen ( J:147868 )

abnormal class switch recombination ( J:147868 )

• most B cells in the spleen undergo class switching unlike in wild-type cells

increased leukocyte cell number ( J:147868 )

increased plasma cell number ( J:147868 )

• when bone marrow cells are transplanted into wild-type mice they accumulate plasma cells unlike when wild-type cells are transplanted

increased memory T cell number ( J:147868 )

• when bone marrow cells are transplanted into wild-type mice they accumulate CD44^highCD62L- T cells unlike when wild-type cells are transplanted

increased immunoglobulin level ( J:147868 )

• hyperimmunoglobulinemia

increased IgA level ( J:147868 )

increased IgG1 level ( J:147868 )

increased IgG2a level ( J:147868 )

increased IgG2b level ( J:147868 )

increased IgG3 level ( J:147868 )

increased IgM level ( J:147868 )

enlarged lymph nodes ( J:147868 )

• mice exhibit lymphadenopathy

• when bone marrow cells are transplanted into wild-type mice they develop lymphadenopathy unlike when wild-type cells are transplanted

increased interferon-gamma secretion ( J:147868 )

• in anti-CD3 antibodies-stimulated spleen cells

increased interleukin-12b secretion ( J:147868 )

• macrophages stimulated with TLR ligands exhibit increased IL12b production compared to wild-type cells

increased interleukin-6 secretion ( J:147868 )

• macrophages stimulated with TLR ligands exhibit increased IL6 production compared to wild-type cells

increased anti-nuclear antigen antibody level ( J:147868 )

increased anti-double stranded DNA antibody level ( J:147868 )

abnormal acute inflammation ( J:147868 )

• mice exhibit infiltration of plasma cells in the lungs, paraepithelium of the bile duct, and pancreas unlike in wild-type mice

• plasma cells accumulate in the lymph nodes and spleens unlike in wild-type mice

• however, intestine and joints exhibit no inflammatory changes

granulomatous inflammation ( J:147868 )

• in the lymph nodes leading to the generation of giant cells with fused macrophages unlike in wild-type mice

abnormal cell physiology ( J:147868 )

• the half-life of IL6 in stimulated macrophages is increased compared to in wild-type mice

postnatal growth retardation ( J:147868 )

enlarged spleen ( J:147868 )

abnormal class switch recombination ( J:147868 )

• most B cells in the spleen undergo class switching unlike in wild-type cells

anemia ( J:147868 )

• severe

abnormal proerythroblast morphology ( J:147868 )

• the number of Ter119+ erythroblast population in the spleen is higher than in wild-type mice

decreased hematocrit ( J:147868 )

decreased hemoglobin content ( J:147868 )

thrombocytosis ( J:147868 )