Phenotypes associated with this allele

• Allele Symbol: Itga3^tm1Rdav
• Allele Name: targeted mutation 1, Ronald Davis
• Allele ID: MGI:3843044
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Itga3^tm1Rdav/Itga3^tm1Rdav Tg(Camk2a-cre)T29-1Stl/0	B6.Cg-Itga3^tm1Rdav Tg(Camk2a-cre)T29-1Stl	MGI:3843051

Genotype
MGI:3843051

cn1

• Allelic Composition: Itga3^tm1Rdav/Itga3^tm1Rdav; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: B6.Cg-Itga3^tm1Rdav Tg(Camk2a-cre)T29-1Stl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial working memory ( J:147820 )

• in a nonmatch-to-place T-maze assay, mice exhibit impaired working memory following a 20 second delay between trials

• however, mice trained in a Morris water maze perform normally

nervous system

reduced long-term potentiation ( J:147820 )

• N-methyl-D-aspartic acid receptor-dependent long term potentiation (LTP) is severely impaired compared to in wild-type mice

• however, glutamate receptor-dependent and high frequency-stimulated LTP are normal