Analysis Tools
mortality/aging
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• all mice die by prematurely, but female mice exhibit a shorter life span than male mice (median survival of 29 weeks for females compared with 43 weeks for males)
• Background Sensitivity: mice have a shorter life span than mice on a mixed background containing C57BL/6
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immune system
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• mice exhibit paravascular cell infiltration and thickening of the artery walls unlike in wild-type mice
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• at 4 to 6 months
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• mature B cells in aged mice lack CD23 expression unlike in wild-type mice indicating an age-dependent loss of part of the normal B cell differentiation program
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• fewer transitional B cells with the AA4.1+ phenotype are detected compared to in wild-type mice
• however, the number of total transitional B cells is normal
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• the number of activated B cells in the spleen is more than in wild-type mice
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• in the spleen
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• decreased in number
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• in some mice
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• following ovalbumin immunization, the memory response upon boosting with ovalbumin is 3-fold less than in similarly treated wild-type mice
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• following IgM stimulation, apoptosis of transitional B cells is greater than in wild-type mice
• however, mature B cells exhibit normal apoptosis rates
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• in response to BCR engagement by anti-IgM, B cell proliferation is less than in wild-type mice
• however, B cells exhibit normal proliferation in response to LPS, IL4, anti-CD40 and ODN1668, and IgM proliferation can be restored by co-stimulation with anto-CD40 or IL4
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• prior to ovalbumin immunization, mice exhibit 3-fold more ovalbumin-specific immunoglobins compared to in wild-type mice
• however, the humoral response 14 days after immunization is normal
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• 1.6-fold at 10 months of age
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• 3.7-fold
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• Background Sensitivity: mice develop systemic lupus erythematosus symptoms earlier in life than when mice are on a mixed background containing FVB/N
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• interstitial
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renal/urinary system
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• interstitial
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• glomeruli are enlarged and often filled with homogeneous protein deposits in the kidney, spleen, liver, and lungs unlike in wild-type mice
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cardiovascular system
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• mice exhibit paravascular cell infiltration and thickening of the artery walls unlike in wild-type mice
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hematopoietic system
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• following IgM stimulation, apoptosis of transitional B cells is greater than in wild-type mice
• however, mature B cells exhibit normal apoptosis rates
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• in response to BCR engagement by anti-IgM, B cell proliferation is less than in wild-type mice
• however, B cells exhibit normal proliferation in response to LPS, IL4, anti-CD40 and ODN1668, and IgM proliferation can be restored by co-stimulation with anto-CD40 or IL4
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• at 4 to 6 months
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• mature B cells in aged mice lack CD23 expression unlike in wild-type mice indicating an age-dependent loss of part of the normal B cell differentiation program
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• fewer transitional B cells with the AA4.1+ phenotype are detected compared to in wild-type mice
• however, the number of total transitional B cells is normal
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• with islands of granulopoiesis
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• 4- to 20-fold in the spleen
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• the number of activated B cells in the spleen is more than in wild-type mice
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• in the spleen
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• decreased in number
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• 1.6-fold at 10 months of age
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• 3.7-fold
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cellular
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• following IgM stimulation, apoptosis of transitional B cells is greater than in wild-type mice
• however, mature B cells exhibit normal apoptosis rates
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• in response to BCR engagement by anti-IgM, B cell proliferation is less than in wild-type mice
• however, B cells exhibit normal proliferation in response to LPS, IL4, anti-CD40 and ODN1668, and IgM proliferation can be restored by co-stimulation with anto-CD40 or IL4
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growth/size/body
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• at 4 to 6 months
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:147840 | |
