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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr9M5Btlr
mutation 5, Bruce Beutler
MGI:3843064
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tlr9M5Btlr/Tlr9+ C57BL/6J-Tlr9M5Btlr MGI:3843071
ot2
 		Tlr9M5Btlr/? C57BL/6J-Tlr9M5Btlr MGI:3843073


Genotype
MGI:3843071
ht1
Allelic
Composition		 Tlr9M5Btlr/Tlr9+
Genetic
Background		 C57BL/6J-Tlr9M5Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M5Btlr mutation (1 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-alpha secretion ( J:147856 )
• the index mouse was identified in a screen of G1 progeny of an ENU mutagenized mouse for reduced type I interferon (IFN) response to in vivo challenge with unmethylated CpG oligonucleotides
decreased interferon-beta secretion ( J:147856 )
• the index mouse was identified in a screen of G1 progeny of an ENU mutagenized mouse for reduced type I interferon (IFN) response to in vivo challenge with unmethylated CpG oligonucleotides




Genotype
MGI:3843073
ot2
Allelic
Composition		 Tlr9M5Btlr/?
Genetic
Background		 C57BL/6J-Tlr9M5Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr9M5Btlr mutation (1 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:147856 )
• macrophages isolated from CpG6 mutant mice do not produce tumor necrosis factor (TNF)-alpha upon exposure to CpG oligonucleotides
• responses of mutant macrophages to other Toll-like receptor (TLR) ligands are normal
decreased tumor necrosis factor secretion ( J:147856 )
• macrophages isolated from CpG6 mutant mice do not produce tumor necrosis factor (TNF)-alpha upon exposure to CpG oligonucleotides

hematopoietic system
abnormal macrophage physiology ( J:147856 )
• macrophages isolated from CpG6 mutant mice do not produce tumor necrosis factor (TNF)-alpha upon exposure to CpG oligonucleotides
• responses of mutant macrophages to other Toll-like receptor (TLR) ligands are normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory