Allele Symbol Allele Name Allele ID |
Hbbtm1.1(HBG1,HBB*)Ryan targeted mutation 1.1, Thomas M Ryan MGI:3843171 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• seen in adults
• results in the release of nascent macrocytic red blood cells and reticulocytes into circulation
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• enlarged femoral bone marrow cavities are filled with erythroid progenitors
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• the red cell distribution width is double that of controls
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• numerous targeted and hypochromic red cells are present
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• about a 9 fold increase in reticulocyte counts
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• 6 fold increase in size, as a percentage of body weight
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• destruction of erythroid cells leads to increased deposition of iron in the spleen
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• splenic architecture is disrupted by the expansion of the red pulp
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• enlarged femoral bone marrow cavity
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• destruction of erythroid cells leads to increased deposition of iron in the bone marrow
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• destruction of erythroid cells leads to increased deposition of iron in the spleen
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• destruction of erythroid cells leads to increased deposition of iron in the liver
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• destruction of erythroid cells leads to increased deposition of iron in the liver
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• 6 fold increase in size, as a percentage of body weight
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• destruction of erythroid cells leads to increased deposition of iron in the spleen
|
• splenic architecture is disrupted by the expansion of the red pulp
|
• 6 fold increase in size, as a percentage of body weight
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
beta thalassemia | DOID:12241 |
OMIM:613985 |
J:147906 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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