Analysis Tools
mortality/aging
|
• about 25% of mice die within 10 days of birth while the remaining 75% have a normal lifespan
|
|
• about 25% of mice die within 10 days of birth
|
skeleton
|
• moderate decrease in the length of long bones in newborns
• decrease in length becomes more severe with age
|
short femur
(
J:148004
)
|
• severe kyphoscoliosis develops in mice that die by P10
|
|
• reduction in growth of the long bones
• growth of the skull is abnormal
|
|
• proliferating chondrocytes have a more rounded morphology and the columnar structure is disorganized in newborns
• these abnormalities become more pronounced with age
• at 4 weeks of age the height of the proliferative zone is reduced to a few cells and significantly fewer cells are proliferating
|
|
• in newborns the percentage of binucleated cells is increased and this percentage continues to increase with age
• at 4 weeks of age many cells are unusually enlarged and appear binucleated
|
|
• increased height in newborns
|
|
• isolated chondrocytes remain rounded, failing to form and extend lamellipodia
|
|
• isolated chondrocytes appear to have a defect in cytokinesis and show a marked delay in daughter cell separation
|
growth/size/body
|
• mice that die by P10 are smaller
• progressive development of dwarfism in surviving mice
|
behavior/neurological
limbs/digits/tail
short femur
(
J:148004
)
