About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Septin12tm1.1Plk
targeted mutation 1.1, Pao-Lin Kuo
MGI:3843373
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Septin12tm1.1Plk/Septin12+ chimera involves: 129/Sv * C57BL/6 MGI:3843449


Genotype
MGI:3843449
ht1
Allelic
Composition		 Septin12tm1.1Plk/Septin12+
Genetic
Background		 chimera involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin12tm1.1Plk mutation (0 available); any Septin12 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent sperm flagellum ( J:147965 )
• in some low-expressing chimeras
kinked sperm flagellum ( J:147965 )
• in 36% of sperm from low-expressing chimera and 38% of sperm from high-expressing chimeras
abnormal sperm head morphology ( J:147965 )
• disorganized mitochondria in low-expressing chimeras
abnormal acrosome morphology ( J:147965 )
• in high-expressing chimeras, the acrosome almost fails to form unlike in wild-type mice
globozoospermia ( J:147965 )
• in high-expressing chimeras
detached acrosome ( J:147965 )
• low-expressing chimeras exhibit loose and broken in germ cells unlike in wild-type mice
decreased male germ cell number ( J:147965 )
• some mice exhibit generalized loss of germ cells at all stages unlike in wild-type mice
asthenozoospermia ( J:147965 )
• reduced sperm motility
arrest of spermatogenesis ( J:147965 )
• some mice exhibit arrested spermatogenesis at the spermatid stage unlike in wild-type mice

endocrine/exocrine glands

cellular
absent sperm flagellum ( J:147965 )
• in some low-expressing chimeras
kinked sperm flagellum ( J:147965 )
• in 36% of sperm from low-expressing chimera and 38% of sperm from high-expressing chimeras
abnormal sperm head morphology ( J:147965 )
• disorganized mitochondria in low-expressing chimeras
abnormal acrosome morphology ( J:147965 )
• in high-expressing chimeras, the acrosome almost fails to form unlike in wild-type mice
globozoospermia ( J:147965 )
• in high-expressing chimeras
detached acrosome ( J:147965 )
• low-expressing chimeras exhibit loose and broken in germ cells unlike in wild-type mice
decreased male germ cell number ( J:147965 )
• some mice exhibit generalized loss of germ cells at all stages unlike in wild-type mice
asthenozoospermia ( J:147965 )
• reduced sperm motility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory