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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Septin12tm1.1Plk
targeted mutation 1.1, Pao-Lin Kuo
MGI:3843373
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Septin12tm1.1Plk/Septin12+ chimera involves: 129/Sv * C57BL/6 MGI:3843449


Genotype
MGI:3843449
ht1
Allelic
Composition		 Septin12tm1.1Plk/Septin12+
Genetic
Background		 chimera involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin12tm1.1Plk mutation (0 available); any Septin12 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent sperm flagellum ( J:147965 )
• in some low-expressing chimeras
kinked sperm flagellum ( J:147965 )
• in 36% of sperm from low-expressing chimera and 38% of sperm from high-expressing chimeras
abnormal sperm head morphology ( J:147965 )
• disorganized mitochondria in low-expressing chimeras
abnormal acrosome morphology ( J:147965 )
• in high-expressing chimeras, the acrosome almost fails to form unlike in wild-type mice
globozoospermia ( J:147965 )
• in high-expressing chimeras
detached acrosome ( J:147965 )
• low-expressing chimeras exhibit loose and broken in germ cells unlike in wild-type mice
decreased male germ cell number ( J:147965 )
• some mice exhibit generalized loss of germ cells at all stages unlike in wild-type mice
asthenozoospermia ( J:147965 )
• reduced sperm motility
arrest of spermatogenesis ( J:147965 )
• some mice exhibit arrested spermatogenesis at the spermatid stage unlike in wild-type mice

endocrine/exocrine glands

cellular
absent sperm flagellum ( J:147965 )
• in some low-expressing chimeras
kinked sperm flagellum ( J:147965 )
• in 36% of sperm from low-expressing chimera and 38% of sperm from high-expressing chimeras
abnormal sperm head morphology ( J:147965 )
• disorganized mitochondria in low-expressing chimeras
abnormal acrosome morphology ( J:147965 )
• in high-expressing chimeras, the acrosome almost fails to form unlike in wild-type mice
globozoospermia ( J:147965 )
• in high-expressing chimeras
detached acrosome ( J:147965 )
• low-expressing chimeras exhibit loose and broken in germ cells unlike in wild-type mice
decreased male germ cell number ( J:147965 )
• some mice exhibit generalized loss of germ cells at all stages unlike in wild-type mice
asthenozoospermia ( J:147965 )
• reduced sperm motility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory