About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lattm1.1Wz
targeted mutation 1.1, Weiguo Zhang
MGI:3843455
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Lattm1Les/Lattm1.1Wz involves: C57BL/6 MGI:3843486
cn2
 		Lattm1Les/Lattm1.1Wz
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:3843484


Genotype
MGI:3843486
ht1
Allelic
Composition		 Lattm1Les/Lattm1.1Wz
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1.1Wz mutation (0 available); any Lat mutation (10 available)
Lattm1Les mutation (0 available); any Lat mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal effector T cell morphology ( J:147946 )
• the percentage of mature T cells in the periphery is lower than in wild-type mice
• however, thymocyte development is otherwise normal

immune system
abnormal effector T cell morphology ( J:147946 )
• the percentage of mature T cells in the periphery is lower than in wild-type mice
• however, thymocyte development is otherwise normal




Genotype
MGI:3843484
cn2
Allelic
Composition		 Lattm1Les/Lattm1.1Wz
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1.1Wz mutation (0 available); any Lat mutation (10 available)
Lattm1Les mutation (0 available); any Lat mutation (10 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:147946 )
• based on marker expression, thymocyte positive selection is impaired and single positive thymocyte development is blocked unlike in wild-type mice
increased double-positive T cell number ( J:147946 )
• the percentage of double positive thymocytes is slightly increased compared to in wild-type mice
• however, the absolute numbers of double positive thymocytes are normal
increased gamma-delta T cell number ( J:147946 )
• the percentage of gamma delta T cells is increased compared to in wild-type mice
abnormal effector T cell morphology ( J:147946 )
• the number of mature T cells is decreased compared to in wild-type mice
• few mature T cells are GFP+
decreased CD4-positive, alpha-beta T cell number ( J:147946 )
• the number of CD4+ T cells is decreased 10-fold compared to in wild-type mice
• the CD4+ T cells that remain are GFP-
decreased CD8-positive, alpha-beta T cell number ( J:147946 )
• the number of CD8+ T cells is decreased 20-fold compared to in wild-type mice
• the CD8+ T cells that remain are GFP-
• however, the number of immature single positive cells is normal
abnormal T cell physiology ( J:147946 )
• TCR-mediated calcium fluxes are abrogated unlike in wild-type mice

hematopoietic system
abnormal T cell differentiation ( J:147946 )
• based on marker expression, thymocyte positive selection is impaired and single positive thymocyte development is blocked unlike in wild-type mice
increased double-positive T cell number ( J:147946 )
• the percentage of double positive thymocytes is slightly increased compared to in wild-type mice
• however, the absolute numbers of double positive thymocytes are normal
increased gamma-delta T cell number ( J:147946 )
• the percentage of gamma delta T cells is increased compared to in wild-type mice
abnormal effector T cell morphology ( J:147946 )
• the number of mature T cells is decreased compared to in wild-type mice
• few mature T cells are GFP+
decreased CD4-positive, alpha-beta T cell number ( J:147946 )
• the number of CD4+ T cells is decreased 10-fold compared to in wild-type mice
• the CD4+ T cells that remain are GFP-
decreased CD8-positive, alpha-beta T cell number ( J:147946 )
• the number of CD8+ T cells is decreased 20-fold compared to in wild-type mice
• the CD8+ T cells that remain are GFP-
• however, the number of immature single positive cells is normal
abnormal T cell physiology ( J:147946 )
• TCR-mediated calcium fluxes are abrogated unlike in wild-type mice

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory