Phenotypes associated with this allele

• Allele Symbol: Tg(Camk2a-UBB*)3413-1Fwvl
• Allele Name: transgene insertion 3413-1, FW van Leeuwen
• Allele ID: MGI:3843483
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Camk2a-UBB*)3413-1Fwvl/?	C57BL/6-Tg(Camk2a-UBB*)3413-1Fwvl	MGI:3843522

Genotype
MGI:3843522

tg1

• Allelic Composition: Tg(Camk2a-UBB*)3413-1Fwvl/?
• Genetic Background: C57BL/6-Tg(Camk2a-UBB*)3413-1Fwvl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:147938 )

• in a fear-conditioning paradigm, 9-month old mice exhibit significantly less freezing behavior on day 8 after training than wild-type littermates; however, cued-conditioning behavior is similar in transgenic and wild-type littermates

abnormal spatial reference memory ( J:147938 )

• 9-month old male mice exhibit poor performance in the Morris water maze task in probe trials done 1 week after training commenced; mice show no quadrant preference for the former location of the platform, in contrast to wild-type mice, and significantly larger distance to platform travel compared to wild-type