Allele Symbol Allele Name Allele ID |
Tg(Hspa2-cre)1Eddy transgene insertion 1, Edward M Eddy MGI:3843498 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• testis weight to body weight and seminal vesicle weight to body weight ratios are normal
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• sperm axonemes and accessory structures appear disorganized
• "9 +2" axonemes are not present in the remaining flagella
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• very few flagella are formed
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• epididymidal sperm number is dramatically lower than that in control mice
• epididymides only contain debris and degenerating spermatozoa
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• most of the remaining spermatozoa exhibit round or detached heads
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• spermatids with enlarged redundant nuclear envelopes are observed
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• spermatid tails are not formed properly, and the redundant nuclear envelope appears to be enlarged
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• manchette structures are either disrupted or absent in condensing spermatids
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• remaining epididymidal spermatozoa show no motility
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• most spermatids fail to develop to the elongating stage
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• epididymides only contain debris and degenerating spermatozoa
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• all adult males are sterile
|
|
• sperm axonemes and accessory structures appear disorganized
• "9 +2" axonemes are not present in the remaining flagella
|
|
• very few flagella are formed
|
|
• epididymidal sperm number is dramatically lower than that in control mice
• epididymides only contain debris and degenerating spermatozoa
|
|
• most of the remaining spermatozoa exhibit round or detached heads
|
|
• spermatids with enlarged redundant nuclear envelopes are observed
|
|
• spermatid tails are not formed properly, and the redundant nuclear envelope appears to be enlarged
|
|
• manchette structures are either disrupted or absent in condensing spermatids
|
|
• remaining epididymidal spermatozoa show no motility
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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