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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Drd2-EGFP)S118Gsat
transgene insertion S118, GENSAT Project at Rockefeller University
MGI:3843608
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd2-cre)ER44Gsat/0
Tg(Drd2-EGFP)S118Gsat/0 		involves: C57BL/6 * FVB/N * FVB/NTac MGI:4830460
cx2
 		Del(7Coro1a-Spn)1Dolm/+
Tg(Drd2-EGFP)S118Gsat/0 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6N * CD-1 * FVB/N MGI:5571091
cx3
 		Gprin3em1Sns/Gprin3em1Sns
Tg(Drd2-EGFP)S118Gsat/0 		involves: C57BL/6 * C57BL/6J * CD-1 * FVB/NTac MGI:6363245


Genotype
MGI:4830460
cn1
Allelic
Composition		 Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd2-cre)ER44Gsat/0
Tg(Drd2-EGFP)S118Gsat/0
Genetic
Background		 involves: C57BL/6 * FVB/N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r1btm5.1Pggd mutation (0 available); any Ppp1r1b mutation (18 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
Tg(Drd2-EGFP)S118Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
reduced long-term potentiation ( J:163700 )
• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological
impaired behavioral response to xenobiotic ( J:163700 )
• haloperidol-induced catalepsy is strongly reduced
hyperactivity ( J:163700 )
• in an open-field test




Genotype
MGI:5571091
cx2
Allelic
Composition		 Del(7Coro1a-Spn)1Dolm/+
Tg(Drd2-EGFP)S118Gsat/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6N * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(7Coro1a-Spn)1Dolm mutation (1 available); any Del(7Coro1a-Spn)1Dolm mutation (1 available)
Tg(Drd2-EGFP)S118Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal globus pallidus morphology ( J:210018 )
• enlarged globus pallidus at postnatal day 7
abnormal dorsal striatum morphology ( J:210018 )
• increased numbers of Drd2+ cells in ventral and dorsal striatum
abnormal ventral striatum morphology ( J:210018 )
• increased numbers of Drd2+ cells in ventral and dorsal striatum
increased excitatory postsynaptic current frequency ( J:210018 )
• increased excitatory postsynaptic current frequency in Drd2+ medium spiny neurons




Genotype
MGI:6363245
cx3
Allelic
Composition		 Gprin3em1Sns/Gprin3em1Sns
Tg(Drd2-EGFP)S118Gsat/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CD-1 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gprin3em1Sns mutation (0 available); any Gprin3 mutation (31 available)
Tg(Drd2-EGFP)S118Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendrite morphology ( J:279507 )
• striatonigral medium spiny neurons exhibit reorganization of the dendritic tree without changes in the length of the dendritic segments
• striatopallidal medium spiny neurons exhibit increased dendritic arborization accompanied by a tendency to increase the number of dendritic segments without changes in their length
abnormal nervous system electrophysiology ( J:279507 )
• striatopallidal medium spiny neurons tend to show an increase in cell capacitance, higher resting membrane potential, and overall decreased neuronal excitability
• however, striatonigral medium spiny neurons do not show changes in cell capacitance or in resting membrane potential and cell excitability remains unchanged
• treatment of striatopallidal medium spiny neurons with quinpirole, a D2 receptor agonist, does not modify cell excitability or membrane capacitance as it does in controls
• treatment of striatopallidal medium spiny neurons with quinpirole decreases resting membrane potential




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory