Phenotypes associated with this allele

• Allele Symbol: Tg(CDX2-cre*)189Erf
• Allele Name: transgene insertion 189, Eric R Fearon
• Allele ID: MGI:3843611
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apc^tm1Tno/Apc^tm1Tno Tg(CDX2-cre*)189Erf/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3844297
cn2	Apc^tm1Tno/Apc^+ Tg(CDX2-cre*)189Erf/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3844298

Genotype
MGI:3844297

cn1

• Allelic Composition: Apc^tm1Tno/Apc^tm1Tno; Tg(CDX2-cre*)189Erf/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:148161 )

• animals live only 10-27 days past birth

postnatal lethality, complete penetrance ( J:148161 )

• animals live only 10-27 days past birth

neoplasm

increased colon adenoma incidence ( J:148161 )

• some mice show large numbers of polyploid lesions which show dysplastic adenomatous changes upon microscopic analysis

• in proximal colon, tubular adenomatous glands are observed in place of normal mucosa

digestive/alimentary system

increased colon adenoma incidence ( J:148161 )

• some mice show large numbers of polyploid lesions which show dysplastic adenomatous changes upon microscopic analysis

• in proximal colon, tubular adenomatous glands are observed in place of normal mucosa

intestine polyps ( J:148161 )

• all mice display florid polyposis in the proximal colon and cecum

limbs/digits/tail

short tail ( J:148161 )

• mice often display a short tail

kinked tail ( J:148161 )

• mice often display a crooked tail

Genotype
MGI:3844298

cn2

• Allelic Composition: Apc^tm1Tno/Apc⁺; Tg(CDX2-cre*)189Erf/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

neoplasm

neoplasm ( J:148161 )

N • mice show no signs of disease up to 200 days of age