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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tekt3tm1Zuk
targeted mutation 3, Martin M Matzuk
MGI:3843699
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tekt3tm1Zuk/Tekt3tm1Zuk either: 129S7/SvEvBrd-Tekt3tm1Zuk or (involves: 129S7/SvEvBrd * C57BL/6J) MGI:3843773
cx2
 		Tekt3tm1Zuk/Tekt3tm1Zuk
Tekt4tm1Zuk/Tekt4tm1Zuk 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3843774


Genotype
MGI:3843773
hm1
Allelic
Composition		 Tekt3tm1Zuk/Tekt3tm1Zuk
Genetic
Background		 either: 129S7/SvEvBrd-Tekt3tm1Zuk or (involves: 129S7/SvEvBrd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tekt3tm1Zuk mutation (0 available); any Tekt3 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Structural defects in Tekt3tm1Zuk/Tekt3tm1Zuk spermatozoa flagella

reproductive system
reproductive system phenotype ( J:148050 )
N
• despite abnormal sperm motility, male mice exhibit normal fertility
hairpin sperm flagellum ( J:148050 )
• mutant sperm frequently exhibit flagellar bending (typically up to 180 degrees) at the annulus at the junction of the midpiece and the principal piece
asthenozoospermia ( J:148050 )
• the percentage of motile spermatozoa is reduced compared to in wild-type mice
• sperm exhibit defective flagellar beat pattern and lack of forward progression unlike wild-type sperm

cellular
hairpin sperm flagellum ( J:148050 )
• mutant sperm frequently exhibit flagellar bending (typically up to 180 degrees) at the annulus at the junction of the midpiece and the principal piece
asthenozoospermia ( J:148050 )
• the percentage of motile spermatozoa is reduced compared to in wild-type mice
• sperm exhibit defective flagellar beat pattern and lack of forward progression unlike wild-type sperm




Genotype
MGI:3843774
cx2
Allelic
Composition		 Tekt3tm1Zuk/Tekt3tm1Zuk
Tekt4tm1Zuk/Tekt4tm1Zuk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tekt3tm1Zuk mutation (0 available); any Tekt3 mutation (25 available)
Tekt4tm1Zuk mutation (0 available); any Tekt4 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

cellular




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory