All Phenotypes Egr3<tm1(cre)Mod> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Egr3^tm1(cre)Mod
targeted mutation 1, Michael J O'Donovan
MGI:3843775

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Egr3^tm1(cre)Mod/Egr3^tm1(cre)Mod Ntf3^tm2Jae/Ntf3^tm2Jae	involves: 129S1/Sv * C57BL/6	MGI:3843809
cn2	Gdnf^tm1.1Neas/Gdnf^tm1.1Neas Egr3^tm1(cre)Mod/Egr3^tm1(cre)Mod	involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL	MGI:4456169
cn3	Gdnf^tm1Bbd/Gdnf^tm1.1Neas Egr3^tm1(cre)Mod/Egr3⁺	involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL	MGI:4456170

Allelic Composition	Egr3^tm1(cre)Mod/Egr3^tm1(cre)Mod Ntf3^tm2Jae/Ntf3^tm2Jae
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3^tm1(cre)Mod mutation (0 available); any Egr3 mutation (17 available)
Ntf3^tm2Jae mutation (1 available); any Ntf3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:147957 )

abnormal posture ( J:147957 )

• mice show a flexed posture when inverted, similar to Erbb2 conditional mutants

abnormal gait ( J:147957 )

• mice exhibit a wide-based, ataxic gait, similar to Erbb2 conditional mutants; onset of abnormalities is delayed and is less pronounced, however, relative to Erbb2 conditional animals

nervous system

nervous system phenotype ( J:147957 )

N	• functional specificity of connections between afferents and motor neurons is preserved in conditional mutants • anatomical specificity of connections between muscle afferents projecting to agonistic and antagonistic motor neurons is preserved in conditional mutants

abnormal nervous system electrophysiology ( J:147957 )

• at P5, ventral root potentials are normal, but by P14, amplitudes of potentials are reduced by >80% compared to controls

Allelic Composition	Gdnf^tm1.1Neas/Gdnf^tm1.1Neas Egr3^tm1(cre)Mod/Egr3^tm1(cre)Mod
Genetic Background	involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3^tm1(cre)Mod mutation (0 available); any Egr3 mutation (17 available)
Gdnf^tm1.1Neas mutation (1 available); any Gdnf mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cholinergic neuron morphology ( J:160727 )

• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice

decreased motor neuron number ( J:160727 )

• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice

• mice exhibit a depletion in gamma-motor neurons at a similar time course as observed in Egr3^tm1Jmi homozygotes

muscle

muscle phenotype ( J:160727 )

N	• mice exhibit normal muscle spindle morphology

Allelic Composition	Gdnf^tm1Bbd/Gdnf^tm1.1Neas Egr3^tm1(cre)Mod/Egr3⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cholinergic neuron morphology ( J:160727 )

• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice

decreased motor neuron number ( J:160727 )

• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice

• mice exhibit selective loss of gamma-motor neurons compared with wild-type mice

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