Analysis Tools
homeostasis/metabolism
|
• when mice are fed a high fat diet fasting glucose levels are increased compared to diet matched wild-type controls
|
|
• when mice are fed a high fat diet fasting insulin levels are increased compared to diet matched wild-type controls
|
|
• on a high fat diet hepatic gluconeogenesis is enhanced compared to diet matched controls
|
|
• more severe insulin resistance compared to diet matched wild-type controls
|
|
• increase in liver triacylglycerol levels in mice on a high fat diet compared to diet matched wild-type controls
|
liver/biliary system
|
• increase in liver triacylglycerol levels in mice on a high fat diet compared to diet matched wild-type controls
|
muscle
|
• decrease in glucose uptake in skeletal muscles in mice on a high fat diet compared to diet matched wild-type controls
• in isolated skeletal muscle cells from mice on a high fat diet insulin stimulated glucose uptake capacity is significantly decreased compared to diet matched wild-type controls
|
growth/size/body
| N |
• on standard chow or high fat diets no differences in body weight are detected compared to diet matched wild-type mice
• the basic phenotype for these mice is stated to be similar to that of mice homozygous for Cpt1ctm1Mdln
|
cellular
|
• decrease in glucose uptake in skeletal muscles in mice on a high fat diet compared to diet matched wild-type controls
• in isolated skeletal muscle cells from mice on a high fat diet insulin stimulated glucose uptake capacity is significantly decreased compared to diet matched wild-type controls
|
