All Phenotypes Nes<tm1Dopa> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nes^tm1Dopa/Nes^tm1Dopa	involves: 129P2/OlaHsd * C57BL/6J	MGI:4410465
cx2	Nes^tm1Dopa/Nes^tm1Dopa Vim^tm1Cba/Vim^tm1Cba	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J	MGI:4939496

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:168641 )

• of the three mice born, two die 3 weeks after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:168641 )

• 90% of mice die between E8.5 and E12.5

embryonic lethality between implantation and placentation, incomplete penetrance ( J:168641 )

• mice begin to die around E8.5

nervous system

abnormal neuron differentiation ( J:168641 )

• cultured neural stem cells exhibit decreased self-renewal ability and increased apoptosis compared to in wild-type mice

decreased neuronal precursor cell number ( J:168641 )

• fewer neural stem cells are found in the neuroepithelium of the developing neural tube compared to in wild-type mice

embryo

decreased embryo size ( J:168641 )

• at E8.5

growth/size/body

decreased embryo size ( J:168641 )

• at E8.5

decreased birth body size ( J:168641 )

• in three mice born

cellular

abnormal neuron differentiation ( J:168641 )

• cultured neural stem cells exhibit decreased self-renewal ability and increased apoptosis compared to in wild-type mice

Allelic Composition	Nes^tm1Dopa/Nes^tm1Dopa Vim^tm1Cba/Vim^tm1Cba
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nes^tm1Dopa mutation (0 available); any Nes mutation (82 available)
Vim^tm1Cba mutation (2 available); any Vim mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:168641 )

• cultured neural stem cells exhibit increased apoptosis compared to in wild-type mice

cellular

abnormal neuron differentiation ( J:168641 )

• cultured neural stem cells exhibit increased apoptosis compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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