Phenotypes associated with this allele

• Allele Symbol: Tfb1m^tm1.1Lrsn
• Allele Name: targeted mutation 1.1, Nils-Goran Larsson
• Allele ID: MGI:3844229
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tfb1m^tm1.1Lrsn/Tfb1m^tm1.1Lrsn Tg(Ckmm-cre)5Khn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL	MGI:3844252

Genotype
MGI:3844252

cn1

• Allelic Composition: Tfb1m^tm1.1Lrsn/Tfb1m^tm1.1Lrsn; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:148166 )

• at 24 weeks of age

cardiovascular system

abnormal myocardial fiber morphology ( J:148166 )

• after 10 weeks, mitochondrial mass in cardiomyocytes increases unlike in wild-type mice

increased heart weight ( J:148166 )

• after 15 weeks

abnormal myocardial fiber physiology ( J:148166 )

• at 15 to 20 weeks, mitochondrial biogenesis in cardiomyocytes is increased compared to in wild-type mice

• at 5 and 20 weeks, respiratory function and mitochondrial ATP production is decreased compared to in wild-type cells

• heart cells exhibit increased mitochondrial transcription but decreased translation compared to in wild-type cells

muscle

abnormal myocardial fiber morphology ( J:148166 )

• after 10 weeks, mitochondrial mass in cardiomyocytes increases unlike in wild-type mice

growth/size/body

increased heart weight ( J:148166 )

• after 15 weeks