Phenotypes associated with this allele

• Allele Symbol: Grik3^tm1Cmul
• Allele Name: targeted mutation 1, Christophe Mulle
• Allele ID: MGI:3844281
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grik3^tm1Cmul/Grik3^tm1Cmul	Not Specified	MGI:3844282

Genotype
MGI:3844282

hm1

• Allelic Composition: Grik3^tm1Cmul/Grik3^tm1Cmul
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synaptic transmission ( J:148310 )

• llow frequency facilitation is reduced at rates of stimulation greater than 0.2 Hz in mossy fiber CA3 synapses

• addition of philanthotoxin-433 fails to reduce low frequency stimulation unlike in wild-type mice

reduced long-term potentiation ( J:148310 )

• reduced but still present

• increasing extracellular K+ before and during induction or use of a more robust induction protocol rescues long term potentiation

decreased post-tetanic potentiation ( J:148310 )

• decrease in the magnitude of post tetanic potentiation following the last tetanic burst

decreased paired-pulse facilitation ( J:148310 )

• smaller mossy fiber paired pulse facilitation at short interstimulus intervals