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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hpsetm1Jpli
targeted mutation 1, Jin-Ping Li
MGI:3844469
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hpsetm1Jpli/Hpsetm1Jpli B6.129-Hpsetm1Jpli MGI:3844475


Genotype
MGI:3844475
hm1
Allelic
Composition
Hpsetm1Jpli/Hpsetm1Jpli
Genetic
Background
B6.129-Hpsetm1Jpli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hpsetm1Jpli mutation (5 available); any Hpse mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mammary glands of virgin Hpsetm1Jpli/Hpsetm1Jpli females show increased branching of the ducts and precocious alveolar structures

cardiovascular system
• in the presence of FGF-2, aortic ring sprouting in culture is greater than for wild-type rings
• subcutaneous implantation of Matrigel containing FGF-2 produces more neovascularization than in similarly treated wild-type mice

hematopoietic system
• hemoglobin content is 2.6-fold higher in FGF-2 Matrigel plugs compared to in similarly treated wild-type mice

endocrine/exocrine glands
• virgin female mice exhibit increased branching of mammary gland ducts and precocious alveolar structures typical of pregnant mice
• however, the width of primary ducts is normal

integument
• virgin female mice exhibit increased branching of mammary gland ducts and precocious alveolar structures typical of pregnant mice
• however, the width of primary ducts is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory