Phenotypes associated with this allele

• Allele Symbol: Itgb3^tm1Aja
• Allele Name: targeted mutation 1, Ararat J Ablooglu
• Allele ID: MGI:3844533
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb3^tm1Aja/Itgb3^tm1Aja	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3844556

Genotype
MGI:3844556

hm1

• Allelic Composition: Itgb3^tm1Aja/Itgb3^tm1Aja
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet physiology ( J:148306 )

• platelets fail to spread on fibrinogen to the extent wild-type platelets do

• platelets exhibit fewer, blunted filopodia even with MnCl2-treatment, ADP-treatment, or sub-saturating amounts of PAR4 agonist

abnormal platelet activation ( J:148306 )

• less fibrinogen binding and decreased phosphorylation of downstream signaling mediators after MnCl2 or ADP treatment indicates decreased "outside-in" signaling

abnormal platelet dense granule physiology ( J:148306 )

• platelets exhibit reduced alpha-granule secretion in response to ADP and epinephrine

homeostasis/metabolism

abnormal platelet physiology ( J:148306 )

• platelets fail to spread on fibrinogen to the extent wild-type platelets do

• platelets exhibit fewer, blunted filopodia even with MnCl2-treatment, ADP-treatment, or sub-saturating amounts of PAR4 agonist

abnormal platelet activation ( J:148306 )

• less fibrinogen binding and decreased phosphorylation of downstream signaling mediators after MnCl2 or ADP treatment indicates decreased "outside-in" signaling

abnormal platelet dense granule physiology ( J:148306 )

• platelets exhibit reduced alpha-granule secretion in response to ADP and epinephrine

decreased susceptibility to induced thrombosis ( J:148306 )

• FeCl3 injury to the carotid artery fails to induce occlusive thrombus within 30 minutes for 7 out of 11 mice

• two mice have partial occlusion that quickly embolizes and two mice have delayed occlusion of 16.4 minutes compared to 9.4 minutes in wild-type

increased bleeding time ( J:148306 )

• median bleeding time is significantly greater than controls despite having normal numbers of platelets