Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-PKD2)#Hwl
• Allele Name: transgene insertion, Han-Woong Lee
• Allele ID: MGI:3844550
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-PKD2)#Hwl/?	involves: FVB/NJ	MGI:3844551

Genotype
MGI:3844551

tg1

• Allelic Composition: Tg(CAG-PKD2)#Hwl/?
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cystic kidneys in Tg(CAG-PKD2)#Hwl/? mice

renal/urinary system

kidney cortex cyst ( J:148377 )

polycystic kidney ( J:148377 )

• bilateral cysts first appearing at 6 months of age

• number and size of cysts increases with age

• cysts develop mostly from proximal tubules but cysts developing form collecting ducts and distal tubules are also seen

• cysts display distinct morphological stages characterized by changes in the morphology of cells lining the cysts from cuboidal to flat

abnormal renal glomerular capsule morphology ( J:148377 )

abnormal renal glomerulus morphology ( J:148377 )

• dilated

abnormal renal tubule morphology ( J:148377 )

• increase in the number of proliferating cells per tubule, located around cysts especially at late cyst stages

• increase in the number of apoptotic cells per tubule mainly at the intermediate stage of cyst formation

growth/size/body

kidney cortex cyst ( J:148377 )

polycystic kidney ( J:148377 )

• bilateral cysts first appearing at 6 months of age

• number and size of cysts increases with age

• cysts develop mostly from proximal tubules but cysts developing form collecting ducts and distal tubules are also seen

• cysts display distinct morphological stages characterized by changes in the morphology of cells lining the cysts from cuboidal to flat

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycystic kidney disease 2		DOID:0110859	OMIM:613095	J:148377