Phenotypes associated with this allele

• Allele Symbol: Elf5^tm1Sin
• Allele Name: targeted mutation 1, Satrajit Sinha
• Allele ID: MGI:3844569
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Elf5^tm1Sin/Elf5^tm1Sin Tg(KRT14-cre)1Amc/0	involves: C57BL/6 * CBA	MGI:3844571
cn2	Elf5^tm1Sin/Elf5^+ Tg(KRT14-cre)1Amc/0	involves: C57BL/6 * CBA	MGI:3844572
cn3	Elf5^tm1Sin/Elf5^tm1Sin Tg(MMTV-cre)4Mam/0	involves: C57BL/6 * FVB	MGI:3844573

Genotype
MGI:3844571

cn1

• Allelic Composition: Elf5^tm1Sin/Elf5^tm1Sin; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:148362 )

N • unlike homozygous mice carrying Tg(MMTV-cre)4Mam , viability of mutants is similar to controls

reproductive system

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition no lobuloalveolar like structures are present and mammary tissue is still composed primarily of adipocytes

♀ • at parturition even after multiple pregnancies the majority of the epithelial architecture displays closed lumens

♀ • at parturition mammary epithelial cells retain characteristics of virgin ductal epithelial cells

♀ • mammary epithelial cells fail to proliferate and fail to undergo functional differentiation

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition no lobuloalveolar like structures are present and mammary tissue is still composed primarily of adipocytes

♀ • at parturition even after multiple pregnancies the majority of the epithelial architecture displays closed lumens

♀ • at parturition mammary epithelial cells retain characteristics of virgin ductal epithelial cells

♀ • mammary epithelial cells fail to proliferate and fail to undergo functional differentiation

lactation failure ( J:148362 )

♀ • unable to lactate even after multiple pregnancies

integument

integument phenotype ( J:148362 )

N • despite recombination in the skin, no gross skin abnormalities are detected

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition no lobuloalveolar like structures are present and mammary tissue is still composed primarily of adipocytes

♀ • at parturition even after multiple pregnancies the majority of the epithelial architecture displays closed lumens

♀ • at parturition mammary epithelial cells retain characteristics of virgin ductal epithelial cells

♀ • mammary epithelial cells fail to proliferate and fail to undergo functional differentiation

lactation failure ( J:148362 )

♀ • unable to lactate even after multiple pregnancies

Genotype
MGI:3844572

cn2

• Allelic Composition: Elf5^tm1Sin/Elf5⁺; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: C57BL/6 * CBA

reproductive system

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition only a low density of lobuloalveolar like structures are seen and only a few of these display features of secretory differentiation in the lumina instead most lumina are filled with condensed secretory materials

♀ • the presence of condensed secretory materials suggests that mammary epithelial cells fail to undergo terminal differentiation

♀ • after multiple pregnancies lobuloalveolar development is partially restored

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition only a low density of lobuloalveolar like structures are seen and only a few of these display features of secretory differentiation in the lumina instead most lumina are filled with condensed secretory materials

♀ • the presence of condensed secretory materials suggests that mammary epithelial cells fail to undergo terminal differentiation

♀ • after multiple pregnancies lobuloalveolar development is partially restored

abnormal lactation ( J:148362 )

♀ • unable to lactate after the first pregnancy

♀ • females are often able to lactate after multiple pregnancies

integument

abnormal mammary gland growth during pregnancy ( J:148362 )

♀ • at parturition only a low density of lobuloalveolar like structures are seen and only a few of these display features of secretory differentiation in the lumina instead most lumina are filled with condensed secretory materials

♀ • the presence of condensed secretory materials suggests that mammary epithelial cells fail to undergo terminal differentiation

♀ • after multiple pregnancies lobuloalveolar development is partially restored

abnormal lactation ( J:148362 )

♀ • unable to lactate after the first pregnancy

♀ • females are often able to lactate after multiple pregnancies

Genotype
MGI:3844573

cn3

• Allelic Composition: Elf5^tm1Sin/Elf5^tm1Sin; Tg(MMTV-cre)4Mam/0
• Genetic Background: involves: C57BL/6 * FVB

mortality/aging

decreased survivor rate ( J:148362 )

• the expected number of mice are born but very few survive, no time of lethality provided

endocrine/exocrine glands

abnormal mammary gland development ( J:148362 )

♀ • surviving females display poorly developed mammary epithelial structures

abnormal lactation ( J:148362 )

♀ • surviving females display severe lactation defects

integument

abnormal mammary gland development ( J:148362 )

♀ • surviving females display poorly developed mammary epithelial structures

abnormal lactation ( J:148362 )

♀ • surviving females display severe lactation defects