Phenotypes associated with this allele

• Allele Symbol: Agr2^tm1.2Erle
• Allele Name: targeted mutation 1.2, David J Erle
• Allele ID: MGI:3844570
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agr2^tm1.2Erle/Agr2^tm1.2Erle	involves: 129S4/SvJae * FVB/N	MGI:3844581

Genotype
MGI:3844581

hm1

• Allelic Composition: Agr2^tm1.2Erle/Agr2^tm1.2Erle
• Genetic Background: involves: 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Agr2^tm1.2Erle/Agr2^tm1.2Erle mice are devoid of intestinal mucus

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:148339 )

• no mucus is present in the small and large intestinal mucosa despite the presence of mucus-producing goblet cells

• aggregates of mast cells are found in the intestinal mucosa

rectal prolapse ( J:148339 )

• rectal prolapse occurs in 5 of 8 mice during the first year of life

increased susceptibility to induced colitis ( J:148339 )

• low dose DSS (1.5%) leads to inflammatory bowel disease with 20% weight loss, bloody stools, and an inflamed intestinal mucosa

hematopoietic system

increased mast cell number ( J:148339 )

• aggregates of mast cells are found in the intestinal mucosa

immune system

increased susceptibility to induced colitis ( J:148339 )

• low dose DSS (1.5%) leads to inflammatory bowel disease with 20% weight loss, bloody stools, and an inflamed intestinal mucosa

increased mast cell number ( J:148339 )

• aggregates of mast cells are found in the intestinal mucosa