Phenotypes associated with this allele

• Allele Symbol: Htr6^tm1Tct
• Allele Name: targeted mutation 1, Laurence H Tercott
• Allele ID: MGI:3844587
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htr6^tm1Tct/Htr6^tm1Tct	involves: 129X1/SvJ * C57BL/6J	MGI:3844588

Genotype
MGI:3844588

hm1

• Allelic Composition: Htr6^tm1Tct/Htr6^tm1Tct
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:148381 )

N • no differences in activity level, anxiety related behaviors, circadian rhythms, acoustic startle response, spatial learning, or responses to amphetamine and physostigmine are seen

hyperactivity elicited by ethanol administration ( J:148381 )

• increase in activity in the first 5 min after injection of 2 g/kg ethanol compared to similarly treated controls

impaired behavioral response to alcohol ( J:148381 )

• decreased sensitivity to alcohol induced ataxia and sedation

• however, mice do not show altered preference for alcohol compared to controls

growth/size/body

growth/size/body region phenotype ( J:148381 )

N • unlike mice homozygous for other null alleles of this gene, body weight is similar to controls