Phenotypes associated with this allele

• Allele Symbol: Il23r^tm1Kuch
• Allele Name: targeted mutation 1, Vijay K Kuchroo
• Allele ID: MGI:3844602
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il23r^tm1Kuch/Il23r^tm1Kuch	C57BL/6-Il23r^tm1Kuch	MGI:3844611

Genotype
MGI:3844611

hm1

• Allelic Composition: Il23r^tm1Kuch/Il23r^tm1Kuch
• Genetic Background: C57BL/6-Il23r^tm1Kuch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive T cell differentiation ( J:148248 )

• after immunization with MOG peptide, there is a greater than 5-fold reduction in the number of Th17 T cells found in the spleen but not in the draining lymph nodes compared to controls

• activating T cells in the presence of IL-23 does not increase the frequency of Th17 T cells as occurs for wild-type T cells

• percentage of memory Th17 T cells is about half that of controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:148248 )

• the memory Th17 T cells found in these mice fail to proliferate in response to activation in the presence of IL-23

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:148248 )

• mice are completely resistant to EAE induced by MOG immunization

• activated T cell blasts from MOG-immunized mutant mice fail to transfer disease to syngenic nave wild-type hosts suggesting resistance to EAE is intrinsic to T cells

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:148248 )

• after immunization with MOG peptide, there is a greater than 5-fold reduction in the number of Th17 T cells found in the spleen but not in the draining lymph nodes compared to controls

• activating T cells in the presence of IL-23 does not increase the frequency of Th17 T cells as occurs for wild-type T cells

• percentage of memory Th17 T cells is about half that of controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:148248 )

• the memory Th17 T cells found in these mice fail to proliferate in response to activation in the presence of IL-23