Phenotypes associated with this allele

• Allele Symbol: Cpn1^tm1Raw
• Allele Name: targeted mutation 1, Rick A Wetsel
• Allele ID: MGI:3844631
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpn1^tm1Raw/Cpn1^tm1Raw	B6.129S1-Cpn1^tm1Raw	MGI:3844644
cx2	C3ar1^tm1Raw/C3ar1^tm1Raw Cpn1^tm1Raw/Cpn1^tm1Raw	B6.129-C3ar1^tm1Raw Cpn1^tm1Raw	MGI:3844645

Genotype
MGI:3844644

hm1

• Allelic Composition: Cpn1^tm1Raw/Cpn1^tm1Raw
• Genetic Background: B6.129S1-Cpn1^tm1Raw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal complement pathway ( J:148315 )

• mice are hypersensitive to anaphylactic shock caused by acute complement activation when administered cobra venom factor or C5a complement

increased acute inflammation ( J:148315 )

• more mice die than controls when administered complement-activating cobra venom (8 of 15 vs. 2 of 16 wild-type mice)

• all mice die from anaphylactic shock when administered C5a complement compared to no mortality in wild-type mice treated in a similar manner

• histamine pre-treatment prevents 20% of deaths caused by C5a complement administration

Genotype
MGI:3844645

cx2

• Allelic Composition: C3ar1^tm1Raw/C3ar1^tm1Raw; Cpn1^tm1Raw/Cpn1^tm1Raw
• Genetic Background: B6.129-C3ar1^tm1Raw Cpn1^tm1Raw

immune system

increased acute inflammation ( J:148315 )

• more mice die than controls when administered complement-activating cobra venom (6 of 18 vs. 2 of 16 wild-type mice)