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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm2(Nfatc2*)Rao
targeted mutation 2, Anjana Rao
MGI:3844635
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ MGI:3844640
cn2
Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 MGI:3844643


Genotype
MGI:3844640
cn1
Allelic
Composition
Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Nfatc2*)Rao mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice with this genotype are found

hematopoietic system
• the fraction of B and T cells expressing the recombined allele decreases during differentiation and maturation




Genotype
MGI:3844643
cn2
Allelic
Composition
Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Nfatc2*)Rao mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• hyperresponsive to stimulation
• increased production of IFNG following low level stimulation

homeostasis/metabolism
• increased production of IFNG following low level stimulation

hematopoietic system
• hyperresponsive to stimulation





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory