All Phenotypes Dclk2<tm1.2Jgg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg Dcx^tm1Caw/Dcx^tm1Caw	involves: 129/Sv * C57BL/6	MGI:3844814
cx2	Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg Dcx^tm1Caw/Y	involves: 129/Sv * C57BL/6	MGI:3844816

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:148345 )

• less than 10% of mice survive to 5 months of age

postnatal lethality, incomplete penetrance ( J:148345 )

• about half the die mice before weaning

behavior/neurological

convulsive seizures ( J:148345 )

• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures

• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency

• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions

tonic-clonic seizures ( J:148345 )

• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus

• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

nervous system

convulsive seizures ( J:148345 )

• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures

• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency

• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions

tonic-clonic seizures ( J:148345 )

• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus

• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

abnormal brain interneuron morphology ( J:148345 )

• CaBP+ interneurons that interact with pyramidal neurons are improperly laminated within the stratum radiatum-lacunosum moleculare border

abnormal dentate gyrus morphology ( J:148345 )

• mice have reduced packing density of the dentate granule neuron layer, resulting in an increased thickness

abnormal hippocampal mossy fiber morphology ( J:148345 )

• mossy fibers fail to separate into the infrapyramidal and the suprapyrimidal bundles and, as a result, mossy fibers travel aberrantly within the pyramidal layer

abnormal hippocampus granule cell layer ( J:148345 )

• lamination density of the granule cell layer is increased in these mice

abnormal hippocampus pyramidal cell morphology ( J:148345 )

• pyramidal neurons displayed a striking simplification of apical dendritic arbors with decreased branching from both primary and secondary apical dendrites

abnormal hippocampus region morphology ( J:148345 )

• about half of the somatostatin neurons are selectively lost in the hippocampus by day 18 after birth

abnormal hippocampus CA1 region morphology ( J:148345 )

• about 40% of neurons are displaced into the stratum oriens

abnormal hippocampus CA3 region morphology ( J:148345 )

• the CA3 region is dyslaminated with a small percentage of neurons heterotopically located in the stratum oriens

abnormal inhibitory postsynaptic currents ( J:148345 )

• the frequency of spontaneous sIPSC among pyramidal neurons is severely reduced by 55% compared to controls

Allelic Composition	Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg Dcx^tm1Caw/Y
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk2^tm1.2Jgg mutation (1 available); any Dclk2 mutation (135 available)
Dcx^tm1Caw mutation (0 available); any Dcx mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hippocampal disorganization, increased c-fos, and loss of SOM+ interneurons in Dcx^tm1Caw/Y Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg mice

mortality/aging

premature death ( J:148345 )

• less than 10% of mice survive to 5 months of age

postnatal lethality, incomplete penetrance ( J:148345 )

• about half the die mice before weaning

behavior/neurological

convulsive seizures ( J:148345 )

• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures

• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency

• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions

tonic-clonic seizures ( J:148345 )

• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus

• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

nervous system

convulsive seizures ( J:148345 )

• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures

• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency

• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions

tonic-clonic seizures ( J:148345 )

• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus

• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

abnormal brain interneuron morphology ( J:148345 )

• CaBP+ interneurons that interact with pyramidal neurons are improperly laminated within the stratum radiatum-lacunosum moleculare border

abnormal dentate gyrus morphology ( J:148345 )

• mice have reduced packing density of the dentate granule neuron layer, resulting in an increased thickness

abnormal hippocampal mossy fiber morphology ( J:148345 )

• mossy fibers fail to separate into the infrapyramidal and the suprapyrimidal bundles and, as a result, mossy fibers travel aberrantly within the pyramidal layer

abnormal hippocampus granule cell layer ( J:148345 )

• lamination density of the granule cell layer is increased in these mice

abnormal hippocampus pyramidal cell morphology ( J:148345 )

• pyramidal neurons displayed a striking simplification of apical dendritic arbors with decreased branching from both primary and secondary apical dendrites

abnormal hippocampus region morphology ( J:148345 )

• about half of the somatostatin neurons are selectively lost in the hippocampus by day 18 after birth

abnormal hippocampus CA1 region morphology ( J:148345 )

• about 40% of neurons are displaced into the stratum oriens

abnormal hippocampus CA3 region morphology ( J:148345 )

• the CA3 region is dyslaminated with a small percentage of neurons heterotopically located in the stratum oriens

abnormal inhibitory postsynaptic currents ( J:148345 )

• the frequency of spontaneous sIPSC among pyramidal neurons is severely reduced by 55% compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24