Analysis Tools|
Allele Symbol Allele Name Allele ID |
Extl3tm1.1Okam targeted mutation 1.1, Hiroshi Okamoto MGI:3844734 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• decreased beta-cell area relative to the whole pancreatic area (75%)
• no difference in the islet size
|
|
• decreased beta-cell number/total islet cell number ratio (80%) after 2 weeks of age
|
|
• beta-cells exist also in the most peripheral region of the islets after 2 weeks of age
• glucagonspositive alpha-cells are scattered in the central region after 2 weeks of age
• islets develop normally at birth
|
|
• decreased insulin response to 11.2 mM glucose (47%)
• decreased insulin response to 20 mM KCl (75%)
|
|
• decreased insulin response to 11.2 mM glucose (47%)
• decreased insulin response to 20 mM KCl (75%)
|
|
• decreased plasma insulin levels after glucose loading
|
|
• significantly higher blood glucose levels in the glucose tolerance test
• no peripheral insulin resistance in the insulin tolerance test
|
|
• significantly decreased pancreatic islet beta-cell proliferation activity
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
