Phenotypes associated with this allele

• Allele Symbol: Mapt^{tm2(Hdac1)Jae}
• Allele Name: targeted mutation 2, Rudolf Jaenisch
• Allele ID: MGI:3844981
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapt^tm2(Hdac1)Jae/Mapt^tm2(Hdac1)Jae	involves: 129S4/SvJae * C57BL/6	MGI:3844994

Genotype
MGI:3844994

hm1

• Allelic Composition: Mapt^{tm2(Hdac1)Jae}/Mapt^{tm2(Hdac1)Jae}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus pyramidal cell morphology ( J:148391 )

• the overall level of acetylated lysine on histones is decreased in these neurons compared to controls