Phenotypes associated with this allele

• Allele Symbol: Ptprz1^tm1Vlcg
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3845016
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprz1^tm1Vlcg/Ptprz1^tm1Vlcg	involves: 129S/SvEvBrd * C57BL/6	MGI:3845023

Genotype
MGI:3845023

hm1

• Allelic Composition: Ptprz1^tm1Vlcg/Ptprz1^tm1Vlcg
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:148388 )

N • mice perform normally in a startle hearing test and exhibit normal prepulse inhibition and susceptibility to chemically induced seizures

abnormal spatial working memory ( J:148388 )

• young mice exhibit a reduction in the percentage of correct alternations in a Y-maze compared with wild-type mice

• however, this difference is not observed 30 weeks later

impaired coordination ( J:148388 )

• at 14 and 44 weeks mice exhibit decreased performance on a rotarod over time unlike wild-type mice

abnormal nociception after inflammation ( J:148388 )

• following formalin-induced inflammation, behavioral pain scores at phase 1 and 2 are less than for wild-type mice

• following carrageenan-induced inflammation, mice display a reduction in Hargreaves' withdrawal latency and fail to exhibit a reduction in Von Frey's withdrawal force compared to similarly treated wild-type mice

hypoalgesia ( J:148388 )

• mice exhibit increased time before hind paw shake or lick when tested on a hotplate at 50 and 53 degrees Celcius, delayed withdrawal time in the Hargreaves' plantar test at radiant heats of 136 and 164 mW/cm²/s, and age-dependent increased applied force needed to induce paw withdrawal using an automated Von Frey's plantar aesthesiometer compared to similarly treated wild-type mice

increased thermal nociceptive threshold ( J:148388 )

• mice exhibit increase time before hind paw shake or lick when tested on a hotplate at 50 and 53 degrees Celcius and delayed withdrawal time in the Hargreaves' plantar test at radiant heats of 136 and 164 mW/cm²/s compared to similarly treated wild-type mice

• however, mice react normally to hotplate temperatures of 55 degrees Celcius and radiant heats of 190 mW/cm²/s in the plantar Hargreaves' test

nervous system

nervous system phenotype ( J:148388 )

N • mice exhibit normal central and peripheral conduction times