Analysis Tools
renal/urinary system
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• the iberiotoxin sensitive component of the large noninactivating outward currents induced in urinary bladder smooth muscle cells by membrane depolarization is absent after tamoxifen treatment
• following tamoxifen treatment, peak contractions are more accentuated and maximal contraction is seen at lower electric field stimulation frequencies in detrusor muscle strips with intact urothelium
• following tamoxifen treatment, peak contractions of detrusor muscle strips with intact urothelium are stronger at stimulation frequencies of 1, 2, and 4 Hz compared to mice homozygous for Kcnma1tm1Ruth
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• following tamoxifen treatment, an increase in the number of micturitions following intake of a defined amount of fluid is seen compared to both wild-type mice and mice homozygous for Kcnma1tm1Ruth
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muscle
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• following tamoxifen treatment, peak contractions are more accentuated and maximal contraction is seen at lower electric field stimulation frequencies in detrusor muscle strips with intact urothelium compared to wild-type controls
• following tamoxifen treatment, urinary bladder detrusor muscle is more sensitive to isoproterenol and Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate induced inhibition of contractility compared to controls
• following tamoxifen treatment, peak contractions of detrusor muscle strips with intact urothelium are stronger at stimulation frequencies of 1, 2, and 4 Hz compared to mice homozygous for Kcnma1tm1Ruth
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