Phenotypes associated with this allele

• Allele Symbol: Rho^Tvrm1
• Allele Name: translational research vision model 1
• Allele ID: MGI:3845396
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rho^Tvrm1/Rho^+	C57BL/6J-Rho^Tvrm1	MGI:4455026
cx2	Rho^Tvrm1/Rho^+ Rpe65^rd12/Rpe65^rd12	B6.Cg-Rpe65^rd12 Rho^Tvrm1	MGI:4455028

Genotype
MGI:4455026

ht1

• Allelic Composition: Rho^Tvrm1/Rho⁺
• Genetic Background: C57BL/6J-Rho^Tvrm1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Photoreceptor degeneration in Rho^Tvrm4/Rho⁺ and Rho^Tvrm1/Rho⁺ mutants is rapidly induced by exposure to bright light

vision/eye

photosensitivity ( J:159523 )

• exposure to 12,000 lux of light for only 30 s results in degeneration in 4 of 6 mice

retina photoreceptor degeneration ( J:159523 )

• bright light-induced degeneration of photoreceptors

• exposure to 12,000 lux for 30 or more seconds induces photoreceptor degeneration

• however, under standard housing conditions no degeneration is detected

delayed dark adaptation ( J:159523 )

• mice recover more slowly, with a time constant of 11.5 min and reach an asymptote that falls short of the dark adapted value

homeostasis/metabolism

abnormal retinol level ( J:159523 )

• in extracts of whole eyes collected immediately after exposure to 12,000 lux for 5 mins a trend is seen toward lower levels of all trans-retinols than in wild-type

• however, no difference is detected at 1 h after light exposure

photosensitivity ( J:159523 )

• exposure to 12,000 lux of light for only 30 s results in degeneration in 4 of 6 mice

nervous system

retina photoreceptor degeneration ( J:159523 )

• bright light-induced degeneration of photoreceptors

• exposure to 12,000 lux for 30 or more seconds induces photoreceptor degeneration

• however, under standard housing conditions no degeneration is detected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:159523

Genotype
MGI:4455028

cx2

• Allelic Composition: Rho^Tvrm1/Rho⁺; Rpe65^rd12/Rpe65^rd12
• Genetic Background: B6.Cg-Rpe65^rd12 Rho^Tvrm1

vision/eye

retina photoreceptor degeneration ( J:159523 )

• photoreceptor degeneration without exposure to bright light

• the peripheral retina also shows cell loss but is better preserved than the central retina

retina outer nuclear layer degeneration ( J:159523 )

• at 4 weeks of age, retinas have only 5 rows of cell bodies remaining in the central outer nuclear layer

nervous system

retina photoreceptor degeneration ( J:159523 )

• photoreceptor degeneration without exposure to bright light

• the peripheral retina also shows cell loss but is better preserved than the central retina

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa		DOID:10584	OMIM:PS268000	J:159523