Phenotypes associated with this allele

• Allele Symbol: Wnt4^{tm2(EGFP/cre/ERT2)Amc}
• Allele Name: targeted mutation 2, Andrew P McMahon
• Allele ID: MGI:3845544
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Wnt4^tm2(EGFP/cre/ERT2)Amc/Wnt4^+	involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J	MGI:7543488
cx2	Sox7^tm1.1Dsco/Sox7^+ Wnt4^tm2(EGFP/cre/ERT2)Amc/Wnt4^+	involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J	MGI:7543479

Genotype
MGI:7543488

ht1

• Allelic Composition: Wnt4^{tm2(EGFP/cre/ERT2)Amc}/Wnt4⁺
• Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:338879 )

• although present in normal ratios at E15.5/E16.5, heterozygotes are recovered at lower than Mendelian ratios at weaning; however, increase in lethality between E15.5/E16.5 and weaning does not reach statistical significance

cardiovascular system

cardiovascular system phenotype ( J:338879 )

N • no ventricular septal defects were identified at E15.5

atrioventricular cushion hypoplasia ( J:338879 )

• at E10.5, atrioventricular (AV) endocardial cushions are hypocellular with a significant reduction in mesenchymal cell density relative to wild-type and single Sox7^tm1.1Dsco heterozygous controls

Genotype
MGI:7543479

cx2

• Allelic Composition: Sox7^tm1.1Dsco/Sox7⁺; Wnt4^{tm2(EGFP/cre/ERT2)Amc}/Wnt4⁺
• Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:338879 )

• although present in normal ratios at E15.5/E16.5, double heterozygotes are recovered at lower than Mendelian ratios at weaning; however, increase in lethality between E15.5/E16.5 and weaning does not reach statistical significance

cardiovascular system

atrioventricular cushion hypoplasia ( J:338879 )

• at E10.5, atrioventricular (AV) endocardial cushions are hypocellular with a significant reduction in mesenchymal cell density relative to wild-type and single heterozygous controls

ventricular septal defect ( J:338879 )

• at E15.5, three of 8 (38%) of double heterozygotes develop VSDs, not observed in wild-type or single heterozygous controls

perimembraneous ventricular septal defect ( J:338879 )

• at E15.5, two of 8 double heterozygotes develop perimembranous VSDs

muscular ventricular septal defect ( J:338879 )

• at E15.5, one of 8 double heterozygotes shows a muscular VSD