Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Ckm-Ppargc1a)31Brsp transgene insertion 31, Bruce M Spiegelman MGI:3845815 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mitochondria in muscle cells exhibit increased cellular respiration compared with wild-type cells
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• muscle cells contain increased mitochondrial DNA compared with control cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most muscles in transgenic animals display a red color characteristic of oxidative muscle; in contrast, control muscles are paler in appearance
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• muscles in mutant animals are able to sustain a longer duration of continuous contraction; isolated extensor digitorum longus (EDL) muscles show much greater fatigue resistance compared to control muscle
• muscle fiber diameter loss in response to denervation and fasting is less severe in transgenic animals when compared to controls
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• following 5 weeks of a chronic mild stress (CMS) protocol, transgenic mice do not exhibit the increased immobility in forced swim test or decreased sucrose consumption that is observed in wild-type mice
• however, transgenic mice exhibit decreases in body weight similar to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mitochondria in muscle cells exhibit increased cellular respiration compared with wild-type cells
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• muscle cells contain increased mitochondrial DNA compared with control cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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