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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ckm-Ppargc1a)31Brsp
transgene insertion 31, Bruce M Spiegelman
MGI:3845815
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Surf1tm1Zev/Surf1tm1Zev
Tg(Ckm-Ppargc1a)31Brsp/0
involves: 129S7/SvEvBrd * C57BL/6 MGI:5292125
tg2
Tg(Ckm-Ppargc1a)31Brsp/0 C57BL/6-Tg(Ckm-Ppargc1a)31Brsp MGI:3845825
tg3
Tg(Ckm-Ppargc1a)31Brsp/0 C57BL/6-Tg(Ckm-Ppargc1a)31Brsp/J MGI:5292124


Genotype
MGI:5292125
cx1
Allelic
Composition
Surf1tm1Zev/Surf1tm1Zev
Tg(Ckm-Ppargc1a)31Brsp/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Surf1tm1Zev mutation (0 available); any Surf1 mutation (14 available)
Tg(Ckm-Ppargc1a)31Brsp mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mitochondria in muscle cells exhibit increased cellular respiration compared with wild-type cells
• muscle cells contain increased mitochondrial DNA compared with control cells




Genotype
MGI:3845825
tg2
Allelic
Composition
Tg(Ckm-Ppargc1a)31Brsp/0
Genetic
Background
C57BL/6-Tg(Ckm-Ppargc1a)31Brsp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ckm-Ppargc1a)31Brsp mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• most muscles in transgenic animals display a red color characteristic of oxidative muscle; in contrast, control muscles are paler in appearance
• muscles in mutant animals are able to sustain a longer duration of continuous contraction; isolated extensor digitorum longus (EDL) muscles show much greater fatigue resistance compared to control muscle
• muscle fiber diameter loss in response to denervation and fasting is less severe in transgenic animals when compared to controls

behavior/neurological
• following 5 weeks of a chronic mild stress (CMS) protocol, transgenic mice do not exhibit the increased immobility in forced swim test or decreased sucrose consumption that is observed in wild-type mice
• however, transgenic mice exhibit decreases in body weight similar to wild-type




Genotype
MGI:5292124
tg3
Allelic
Composition
Tg(Ckm-Ppargc1a)31Brsp/0
Genetic
Background
C57BL/6-Tg(Ckm-Ppargc1a)31Brsp/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ckm-Ppargc1a)31Brsp mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mitochondria in muscle cells exhibit increased cellular respiration compared with wild-type cells
• muscle cells contain increased mitochondrial DNA compared with control cells





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory