Analysis Tools
behavior/neurological
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• up to 20 months, no differences in performance on the beam or in cylinder tests are observed relative to controls
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• animals show significant deficits in the open field at 20 months, but not before 16 months
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• in adhesive removal tests, mice exhibit deficits at 13-16 months
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nervous system
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• at 16 months, mice have a 20% reduction relative to wild-type in tyrosine hydroxylase-positive neurons in the substantia nigra pars compacta (SNc)
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