Phenotypes associated with this allele

• Allele Symbol: Tg(CD2-Stat6*V625A*T626A)78Mhk
• Allele Name: transgene insertion 78, Mark H Kaplan
• Allele ID: MGI:3845883
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Il4^tm1Cgn/Il4^tm1Cgn Tg(CD2-Stat6*V625A*T626A)78Mhk/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:4818945
cx2	Hr^hr/Hr^hr Tg(CD2-Stat6*V625A*T626A)78Mhk/0	involves: C3H * SKH1	MGI:5762832
tg3	Tg(CD2-Stat6*V625A*T626A)78Mhk/0	involves: C3H * C57BL/6	MGI:4818943

Genotype
MGI:4818945

cx1

• Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn; Tg(CD2-Stat6*V625A*T626A)78Mhk/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:160119 )

N • mice do not exhibit skin inflammation unlike Tg(CD2-Stat6*V625A*T626A)78Mhk mice

N • mice exhibit normal recovery from retinoic acid treatment

Genotype
MGI:5762832

cx2

• Allelic Composition: Hr^hr/Hr^hr; Tg(CD2-Stat6*V625A*T626A)78Mhk/0
• Genetic Background: involves: C3H * SKH1

vision/eye

eye inflammation ( J:230018 )

• keratitis is seen in 35% of mice by 20 weeks of age

blepharitis ( J:230018 )

• infiltration of a mixed inflammatory cell infiltrate in the dermis of both the upper and lower eyelids

• a lymphocyte-predominant infiltrate containing variable numbers of eosinophils, macrophages, and neutrophils are seen in the substantia propria of the eyelids

• treatment of eyelids with clobetasol reverses blepharitis

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

uveitis ( J:230018 )

• uveitis, with inflammatory exudates in the anterior chamber of the eye

abnormal cornea morphology ( J:230018 )

• corneal disease (neovascular pannus formation) is seen

• cornea exhibits keratinization of the epithelial layer, increased stromal inflammatory cells, neovascularization and corneal edema

• proteinous exudates with cellular infiltrates are seen along with erosion of the Descemente's membrane

abnormal eyelid morphology ( J:230018 )

• eyelid erythema evident as early as 7 weeks of age

• Th2 cytokine expression is increased in eyelids, indicating allergic inflammation

loss of eyelid cilia ( J:230018 )

• excoriations and madarosis evident as early as 7 weeks of age

immune system

eye inflammation ( J:230018 )

• keratitis is seen in 35% of mice by 20 weeks of age

blepharitis ( J:230018 )

• infiltration of a mixed inflammatory cell infiltrate in the dermis of both the upper and lower eyelids

• a lymphocyte-predominant infiltrate containing variable numbers of eosinophils, macrophages, and neutrophils are seen in the substantia propria of the eyelids

• treatment of eyelids with clobetasol reverses blepharitis

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

uveitis ( J:230018 )

• uveitis, with inflammatory exudates in the anterior chamber of the eye

cardiovascular system

abnormal physiological neovascularization ( J:230018 )

• peripheral neovascularization of the cornea, which extends centrally

endocrine/exocrine glands

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

homeostasis/metabolism

edema ( J:230018 )

• periocular edema evident as early as 7 weeks of age

integument

Meibomian gland inflammation ( J:230018 )

• inflammatory infiltrate is seen in the Meibomian glands

loss of eyelid cilia ( J:230018 )

• excoriations and madarosis evident as early as 7 weeks of age

Genotype
MGI:4818943

tg3

• Allelic Composition: Tg(CD2-Stat6*V625A*T626A)78Mhk/0
• Genetic Background: involves: C3H * C57BL/6

behavior/neurological

excessive scratching ( J:160119 )

• resulting in alopecia on the face, back, and other areas

homeostasis/metabolism

impaired skin barrier function ( J:160119 )

• 10 days after retinoic acid treatment, mice exhibit a 4-fold elevation in transepithelial water loss unlike similarly treated wild-type mice

immune system

dermatitis ( J:160119 )

• mice develop skin inflammation that is similar to atopic dermatitis unlike wild-type mice

integument

impaired skin barrier function ( J:160119 )

• 10 days after retinoic acid treatment, mice exhibit a 4-fold elevation in transepithelial water loss unlike similarly treated wild-type mice

dermatitis ( J:160119 )

• mice develop skin inflammation that is similar to atopic dermatitis unlike wild-type mice

alopecia ( J:160119 )

• on the face, back, and other areas secondary to excessive scratching

mixed cellular infiltration to dermis ( J:160119 )

• eosinophils and lymphocytes

thick dermal layer ( J:160119 )

thick epidermis ( J:160119 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:160119