All Phenotypes Nelfb<tm1.2Roli> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nelfb^tm1.2Roli
targeted mutation 1.2, Rong Li
MGI:3846131

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3846183
cx2	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli Trp53^tm1Brd/Trp53⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3846184
cx3	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3846186

Allelic Composition	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nelfb^tm1.2Roli mutation (0 available); any Nelfb mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

No Nelfb^tm1.2Roli/Nelfb^tm1.2Roli embryos develop beyond E5

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:148508 )

• mice begin to die at E6 and all but one mouse die by E13.5

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:148508 )

• mice begin to die at E6

embryo

embryonic growth arrest ( J:148508 )

• mice do not develop beyond E5

abnormal blastocyst morphology ( J:148508 )

• in culture, blastocysts produce abnormal outgrowths with defective or no inner cell mass derivatives

absent inner cell mass ( J:148508 )

• blastocysts fail to form an inner cell mass in culture

• however, cell proliferation in culture is normal

Allelic Composition	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nelfb^tm1.2Roli mutation (0 available); any Nelfb mutation (24 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:148508 )

• no viable mice are produced

Allelic Composition	Nelfb^tm1.2Roli/Nelfb^tm1.2Roli Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:148508 )

• no viable mice are produced

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