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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Scgb1a1-rtTA,-tTS,tetO-CHI3L1)1Eli
transgene insertion 1, Jack A Elias
MGI:3846185
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Chi3l1tm1Eli/Chi3l1tm1Eli
Tg(Scgb1a1-rtTA,-tTS,tetO-CHI3L1)1Eli/0 		involves: 129 * C57BL/6 MGI:3846227
tg2
 		Tg(Scgb1a1-rtTA,-tTS,tetO-CHI3L1)1Eli/0 Not Specified MGI:3846226


Genotype
MGI:3846227
cx1
Allelic
Composition		 Chi3l1tm1Eli/Chi3l1tm1Eli
Tg(Scgb1a1-rtTA,-tTS,tetO-CHI3L1)1Eli/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chi3l1tm1Eli mutation (0 available); any Chi3l1 mutation (29 available)
Tg(Scgb1a1-rtTA,-tTS,tetO-CHI3L1)1Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:148490 )
N
• Th2 responses to OVA sensitization and challenge to the lungs is similar to wild-type controls but is less than in mice homozygous for just the Chi3l1tm1Eli allele




Genotype
MGI:3846226
tg2
Allelic
Composition		 Tg(Scgb1a1-rtTA,-tTS,tetO-CHI3L1)1Eli/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:148490 )
• apoptosis rates of Th2 T cells in lung are reduced compared to controls after challenge with OVA
increased T-helper 2 cell number ( J:148490 )
• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are moderately enhanced compared to wild-type controls
abnormal macrophage morphology ( J:148490 )
• mice have enhanced numbers of alternatively activated macrophages in the lung
• numbers of alternatively activated macrophages are even more enhanced in response to OVA sensitization and challenge

cellular
decreased apoptosis ( J:148490 )
• apoptosis rates of immune cells in the lung after challenge with OVA are reduced compared to controls
decreased T cell apoptosis ( J:148490 )
• apoptosis rates of Th2 T cells in lung are reduced compared to controls after challenge with OVA

hematopoietic system
decreased T cell apoptosis ( J:148490 )
• apoptosis rates of Th2 T cells in lung are reduced compared to controls after challenge with OVA
increased T-helper 2 cell number ( J:148490 )
• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are moderately enhanced compared to wild-type controls
abnormal macrophage morphology ( J:148490 )
• mice have enhanced numbers of alternatively activated macrophages in the lung
• numbers of alternatively activated macrophages are even more enhanced in response to OVA sensitization and challenge




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory