Analysis Tools
immune system
| N |
• Th2 responses to OVA sensitization and challenge to the lungs is similar to wild-type controls but is less than in mice homozygous for just the Chi3l1tm1Eli allele
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Allele Symbol Allele Name Allele ID |
Tg(Scgb1a1-rtTA,-tTS,tetO-CHI3L1)1Eli transgene insertion 1, Jack A Elias MGI:3846185 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Th2 responses to OVA sensitization and challenge to the lungs is similar to wild-type controls but is less than in mice homozygous for just the Chi3l1tm1Eli allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• apoptosis rates of Th2 T cells in lung are reduced compared to controls after challenge with OVA
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• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are moderately enhanced compared to wild-type controls
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• mice have enhanced numbers of alternatively activated macrophages in the lung
• numbers of alternatively activated macrophages are even more enhanced in response to OVA sensitization and challenge
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• apoptosis rates of immune cells in the lung after challenge with OVA are reduced compared to controls
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• apoptosis rates of Th2 T cells in lung are reduced compared to controls after challenge with OVA
|
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• apoptosis rates of Th2 T cells in lung are reduced compared to controls after challenge with OVA
|
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• in mice administered doxycycline, Th2 cell numbers found in the lungs of mice sensitized and challenged with OVA are moderately enhanced compared to wild-type controls
|
|
• mice have enhanced numbers of alternatively activated macrophages in the lung
• numbers of alternatively activated macrophages are even more enhanced in response to OVA sensitization and challenge
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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