Analysis Tools
cellular
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• T cells, macrophages and eosinophils have increased rates of apoptosis in the lungs of mice sensitized and then challenged with OVA compared to controls
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• there is increased number of apoptotic CD4+ T cells in the lungs of mice sensitized and then challenged with OVA compared to controls
• percentage of apoptotic cells is also increased in vitro when T cells are cultured with TNF or Fas-ligand
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• splenocyte proliferation in response to OVA sensitization and challenge is reduced compared to controls
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immune system
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• there is increased number of apoptotic CD4+ T cells in the lungs of mice sensitized and then challenged with OVA compared to controls
• percentage of apoptotic cells is also increased in vitro when T cells are cultured with TNF or Fas-ligand
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• splenocyte proliferation in response to OVA sensitization and challenge is reduced compared to controls
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• numbers of Th2 CD4+ cells are reduced by half in the lung after OVA-plus-alum sensitization and challenge compared to controls
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• alternatively activated macrophage numbers are reduced by half compared to controls in mice that received OVA-plus-alum sensitization and challenge
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• eosinophil recruitment to the lung is impaired after OVA-plus-alum sensitization and challenge compared to controls
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• neutrophil recruitment to the lung is impaired after OVA-plus-alum sensitization and challenge compared to controls
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• antigen specific IgE levels are significantly less than controls after OVA sensitization and challenge
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• numbers of Th2 CD4+ cells are reduced by half in the lung after OVA-plus-alum sensitization and challenge compared to controls
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• dendritic cell recruitment to the lungs is impaired after OVA sensitization and challenge compared to controls
• in addition, expression of the activation markers CD40 and CD86 on these cells are also decreased compared to controls
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• plasmacytoid dendritic cell recruitment to the lung is impaired after OVA sensitization and challenge compared to controls
• in addition, expression of the activation markers CD40 and CD86 on these cells are decreased compared to controls
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• IL-13 secretion is reduced in the lung by more than 80% after OVA-plus-alum sensitization and challenge compared to controls
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• IL-4 secretion is greatly reduced in the lung after OVA-plus-alum sensitization and challenge compared to controls
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hematopoietic system
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• there is increased number of apoptotic CD4+ T cells in the lungs of mice sensitized and then challenged with OVA compared to controls
• percentage of apoptotic cells is also increased in vitro when T cells are cultured with TNF or Fas-ligand
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• splenocyte proliferation in response to OVA sensitization and challenge is reduced compared to controls
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• numbers of Th2 CD4+ cells are reduced by half in the lung after OVA-plus-alum sensitization and challenge compared to controls
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• alternatively activated macrophage numbers are reduced by half compared to controls in mice that received OVA-plus-alum sensitization and challenge
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• eosinophil recruitment to the lung is impaired after OVA-plus-alum sensitization and challenge compared to controls
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• neutrophil recruitment to the lung is impaired after OVA-plus-alum sensitization and challenge compared to controls
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• antigen specific IgE levels are significantly less than controls after OVA sensitization and challenge
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• numbers of Th2 CD4+ cells are reduced by half in the lung after OVA-plus-alum sensitization and challenge compared to controls
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