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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rorbhstp
high stepper
MGI:3846436
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rorbhstp/Rorbhstp C57BL/6J-Rorbhstp/J MGI:3846437
ht2
 		Rorbtm1.1(cre)Hze/Rorbhstp involves: 129S6/SvEvTac * C57BL/6J MGI:7505589


Genotype
MGI:3846437
hm1
Allelic
Composition		 Rorbhstp/Rorbhstp
Genetic
Background		 C57BL/6J-Rorbhstp/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rorbhstp mutation (1 available); any Rorb mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:337403 )
N
• homozygosity shows no impact on hot plate tests for thermal nocioception or von Frey tests for mechanosensation
limb grasping ( J:148753 )
• when picked up by the tail, homozygotes pull the rear legs to the belly
abnormal gait ( J:148753 )
• homozygotes pull each rear leg up to the body as they step

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:148753 )
N
• normal hearing as assessed by ABR

vision/eye
vision/eye phenotype ( J:337403 )
N
• unlike the high stepper 2J and 5J alleles, these homozygotes have normal retinas
retina photoreceptor degeneration ( J:148753 )
• progressive photreceptor cell loss
abnormal retina ganglion layer morphology ( J:148753 )
• homozygotes have misplaced ganglion cells, evident histologically by 2 weeks of age
increased susceptibility to age-related retinal degeneration ( J:148753 )
• histology shows progressive retinal degeneration
abnormal eye electrophysiology ( J:148753 )
• electroretinogram recordings are abnormal

nervous system
abnormal neuron morphology ( J:337403 )
• the femoral nerves have normal numbers of axons in both motor and sensory branches but modest increase in the average area of the motor nerve branch
retina photoreceptor degeneration ( J:148753 )
• progressive photreceptor cell loss




Genotype
MGI:7505589
ht2
Allelic
Composition		 Rorbtm1.1(cre)Hze/Rorbhstp
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rorbhstp mutation (1 available); any Rorb mutation (41 available)
Rorbtm1.1(cre)Hze mutation (1 available); any Rorb mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:337403 )
• compound heterozygotes pull each rear leg up to the body as they step




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory