Phenotypes associated with this allele

• Allele Symbol: Ascl2^tm1.1Cle
• Allele Name: targeted mutation 1.1 Hans Clevers
• Allele ID: MGI:3846671
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ascl2^tm1.1Cle/Ascl2^tm1.1Cle Tg(Cyp1a1-cre)1Dwi/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3846692

Genotype
MGI:3846692

cn1

• Allelic Composition: Ascl2^tm1.1Cle/Ascl2^tm1.1Cle; Tg(Cyp1a1-cre)1Dwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased small intestinal crypt cell apoptosis ( J:148715 )

• cre induction leads to an increase in crypt cell apoptosis

abnormal small intestine crypts of Lieberkuhn morphology ( J:148715 )

• five days after cre-induction, the elongated Olfm4⁺ stem cells at the base of crypts are absent

• by 15 days after cre-induction, stem cells that have escaped recombination of the floxed allele have completely repopulated the crypts

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:148715 )

• five days after cre-induction, the elongated Olfm4⁺ stem cells at the base of crypts are absent

• by 15 days after cre-induction, stem cells that have escaped recombination of the floxed allele have completely repopulated the crypts

cellular

increased small intestinal crypt cell apoptosis ( J:148715 )

• cre induction leads to an increase in crypt cell apoptosis