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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tpt1tm1Kefu
targeted mutation 1, Ken Fujise
MGI:3846761
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tpt1tm1Kefu/Tpt1tm1Kefu 129S6/SvEvTac-Tpt1tm1Kefu MGI:3846782
hm2
 		Tpt1tm1Kefu/Tpt1tm1Kefu B6.129S6-Tpt1tm1Kefu MGI:3846781
hm3
 		Tpt1tm1Kefu/Tpt1tm1Kefu either: 129S6/SvEvTac-Tpt1tm1Kefu or B6.129S6-Tpt1tm1Kefu MGI:3846778
hm4
 		Tpt1tm1Kefu/Tpt1tm1Kefu involves: 129S6/SvEvTac * C57BL/6 MGI:3846780
ht5
 		Tpt1tm1Kefu/Tpt1+ either: 129S6/SvEvTac-Tpt1tm1Kefu or B6.129S6-Tpt1tm1Kefu MGI:3846779


Genotype
MGI:3846782
hm1
Allelic
Composition		 Tpt1tm1Kefu/Tpt1tm1Kefu
Genetic
Background		 129S6/SvEvTac-Tpt1tm1Kefu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1tm1Kefu mutation (0 available); any Tpt1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:148696 )
• no mice are born alive




Genotype
MGI:3846781
hm2
Allelic
Composition		 Tpt1tm1Kefu/Tpt1tm1Kefu
Genetic
Background		 B6.129S6-Tpt1tm1Kefu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1tm1Kefu mutation (0 available); any Tpt1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:148696 )
• no mice are born alive




Genotype
MGI:3846778
hm3
Allelic
Composition		 Tpt1tm1Kefu/Tpt1tm1Kefu
Genetic
Background		 either: 129S6/SvEvTac-Tpt1tm1Kefu or B6.129S6-Tpt1tm1Kefu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1tm1Kefu mutation (0 available); any Tpt1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, incomplete penetrance ( J:148696 )
• fewer than expected mice are found at E3.5

embryo
abnormal blastocyst morphology ( J:148696 )
• 72% of blastocysts cultured for 5 to 7 days exhibit overgrowth of the inner cell mass and giant trophoblasts compared with wild-type blastocysts
• blastocysts do not survive 8 days as do wild-type blastocysts
• of 2 recovered blastocysts, one hatched then displayed abrupt disintegration and fragmentation of the cell mass after attaching and outgrowing for one day while the other failed to attach




Genotype
MGI:3846780
hm4
Allelic
Composition		 Tpt1tm1Kefu/Tpt1tm1Kefu
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1tm1Kefu mutation (0 available); any Tpt1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:148696 )
• no mice are alive at 4 to 6 weeks of age




Genotype
MGI:3846779
ht5
Allelic
Composition		 Tpt1tm1Kefu/Tpt1+
Genetic
Background		 either: 129S6/SvEvTac-Tpt1tm1Kefu or B6.129S6-Tpt1tm1Kefu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpt1tm1Kefu mutation (0 available); any Tpt1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased sensitivity to induced cell death ( J:148696 )
• mouse embryonic fibroblasts challenged with TNF-alpha, 5-fluorouracil, or thapsigargin exhibit increased apoptosis compared with similarly treated wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory