Phenotypes associated with this allele

• Allele Symbol: Sgk1^tm1.2Palm
• Allele Name: targeted mutation 1.2, Lawrence G Palmer
• Allele ID: MGI:3846797
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgk1^tm1.2Palm/Sgk1^tm1.2Palm	129/Sv-Sgk1^tm1.2Palm	MGI:3846803

Genotype
MGI:3846803

hm1

• Allelic Composition: Sgk1^tm1.2Palm/Sgk1^tm1.2Palm
• Genetic Background: 129/Sv-Sgk1^tm1.2Palm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine potassium level ( J:148648 )

• potassium excretion trends higher than controls when mice are put on a salt-restricted diet

• significant differences occur during day-time hours

increased urine sodium level ( J:148648 )

• sodium excretion is higher than controls between 12 and 45 hours after the beginning of salt restriction

• amiloride-sensitive whole-cell current is slightly increased in the collecting ducts after 2 days of salt restriction

homeostasis/metabolism

increased circulating aldosterone level ( J:148648 )

• mice have 4-6 fold higher aldosterone levels than controls when put on a salt-restricted diet

increased urine potassium level ( J:148648 )

• potassium excretion trends higher than controls when mice are put on a salt-restricted diet

• significant differences occur during day-time hours

increased urine sodium level ( J:148648 )

• sodium excretion is higher than controls between 12 and 45 hours after the beginning of salt restriction

• amiloride-sensitive whole-cell current is slightly increased in the collecting ducts after 2 days of salt restriction