Phenotypes associated with this allele

• Allele Symbol: Stk4^tm1.1Kina
• Allele Name: targeted mutation 1.1, Tatsuo Kinashi
• Allele ID: MGI:3847089
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk4^tm1.1Kina/Stk4^tm1.1Kina	involves: C57BL/6	MGI:3847106

Genotype
MGI:3847106

hm1

• Allelic Composition: Stk4^tm1.1Kina/Stk4^tm1.1Kina
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:148791 )

• migration of lymphocytes is impaired in these mice

abnormal leukocyte adhesion ( J:148791 )

• attachment and arrest of T cells to the high endothelial venules of mesenteric lymph nodes is reduced by 65% compared to controls

• attachment and arrest of B cells to the high endothelial venules of mesenteric lymph nodes is 25% of controls

• studies with antibodies indicate that impaired homing is due to defects in stabilization of integrin-dependent arrest

• single-positive thymocyte emigration from the thymus is impaired

decreased myeloid dendritic cell number ( J:148791 )

• conventional DC numbers in the spleen are reduced to about 65% of controls

increased single-positive T cell number ( J:148791 )

• both CD4 and CD8 single-positive thymocyte numbers are increased compared to controls

decreased lymphocyte cell number ( J:148791 )

• lymphocyte numbers are decreased by about two-thirds in the lymph nodes and half in the spleen

decreased B cell number ( J:148791 )

• B cell numbers are decreased in the spleen, Peyer's patches and lymph nodes

decreased T cell number ( J:148791 )

• T cell numbers are decreased in the spleen, Peyer's patches and lymph nodes

abnormal B cell physiology ( J:148791 )

• after transfer into wild-type hosts, trafficking of mutant B cells to spleen and lymph nodes is reduced to one-fourth of controls

• attachment to the high endothelial venules of mesenteric lymph nodes is 25% of controls

abnormal T cell physiology ( J:148791 )

• after transfer into wild-type hosts, trafficking of mutant T cells to spleen and lymph nodes is reduced one-third to one-fourth of controls

• attachment to the high endothelial venules of mesenteric lymph nodes is reduced by 65% compared to controls

increased T cell proliferation ( J:148791 )

• T cells have enhanced proliferation in response to anti-CD3 stimulation

abnormal immune system organ morphology ( J:148791 )

thymus hyperplasia ( J:148791 )

• thymus cell number is over 10% higher than controls

abnormal marginal zone B cell morphology ( J:148791 )

• there are few cells present in the marginal sinus at the border between the white and red pulp

decreased marginal zone B cell number ( J:148791 )

• marginal zone B cells are barely present in the spleen

abnormal spleen B cell follicle morphology ( J:148791 )

• the size and cellularity of B cell follicles are reduced

decreased spleen B cell follicle size ( J:148791 )

abnormal Peyer's patch T cell area morphology ( J:148791 )

• the size and cellularity of T cell follicles are reduced

abnormal Peyer's patch germinal center morphology ( J:148791 )

• the size and cellularity of B cell areas are reduced in the Peyer's patch

abnormal dendritic cell physiology ( J:148791 )

• dendritic cells adhere poorly in vitro to fibronectin and ICAM-1

hematopoietic system

abnormal leukocyte migration ( J:148791 )

• migration of lymphocytes is impaired in these mice

abnormal leukocyte adhesion ( J:148791 )

• attachment and arrest of T cells to the high endothelial venules of mesenteric lymph nodes is reduced by 65% compared to controls

• attachment and arrest of B cells to the high endothelial venules of mesenteric lymph nodes is 25% of controls

• studies with antibodies indicate that impaired homing is due to defects in stabilization of integrin-dependent arrest

• single-positive thymocyte emigration from the thymus is impaired

thymus hyperplasia ( J:148791 )

• thymus cell number is over 10% higher than controls

decreased myeloid dendritic cell number ( J:148791 )

• conventional DC numbers in the spleen are reduced to about 65% of controls

increased single-positive T cell number ( J:148791 )

• both CD4 and CD8 single-positive thymocyte numbers are increased compared to controls

decreased lymphocyte cell number ( J:148791 )

• lymphocyte numbers are decreased by about two-thirds in the lymph nodes and half in the spleen

decreased B cell number ( J:148791 )

• B cell numbers are decreased in the spleen, Peyer's patches and lymph nodes

decreased marginal zone B cell number ( J:148791 )

• marginal zone B cells are barely present in the spleen

decreased T cell number ( J:148791 )

• T cell numbers are decreased in the spleen, Peyer's patches and lymph nodes

abnormal marginal zone B cell morphology ( J:148791 )

• there are few cells present in the marginal sinus at the border between the white and red pulp

abnormal spleen B cell follicle morphology ( J:148791 )

• the size and cellularity of B cell follicles are reduced

decreased spleen B cell follicle size ( J:148791 )

abnormal B cell physiology ( J:148791 )

• after transfer into wild-type hosts, trafficking of mutant B cells to spleen and lymph nodes is reduced to one-fourth of controls

• attachment to the high endothelial venules of mesenteric lymph nodes is 25% of controls

abnormal T cell physiology ( J:148791 )

• after transfer into wild-type hosts, trafficking of mutant T cells to spleen and lymph nodes is reduced one-third to one-fourth of controls

• attachment to the high endothelial venules of mesenteric lymph nodes is reduced by 65% compared to controls

increased T cell proliferation ( J:148791 )

• T cells have enhanced proliferation in response to anti-CD3 stimulation

cellular

abnormal leukocyte migration ( J:148791 )

• migration of lymphocytes is impaired in these mice

abnormal leukocyte adhesion ( J:148791 )

• attachment and arrest of T cells to the high endothelial venules of mesenteric lymph nodes is reduced by 65% compared to controls

• attachment and arrest of B cells to the high endothelial venules of mesenteric lymph nodes is 25% of controls

• studies with antibodies indicate that impaired homing is due to defects in stabilization of integrin-dependent arrest

• single-positive thymocyte emigration from the thymus is impaired

increased T cell proliferation ( J:148791 )

• T cells have enhanced proliferation in response to anti-CD3 stimulation

endocrine/exocrine glands

thymus hyperplasia ( J:148791 )

• thymus cell number is over 10% higher than controls