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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SMN2*)1951Ahmb
transgene insertion 1951, Arthur H M Burghes
MGI:3847329
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*)1951Ahmb/0 		involves: 129P2/OlaHsd * FVB/N MGI:3847444


Genotype
MGI:3847444
cx1
Allelic
Composition		 Smn1tm1Msd/Smn1tm1Msd
Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Tg(SMN2*)1951Ahmb/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm7Tg(SMN2)89Ahmb mutation (34 available); any Grm7 mutation (125 available)
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
Tg(SMN2*)1951Ahmb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:148541 )
• animals have a mean lifespan of 6.5 days compared to spinal muscular atrophic (SMA) animals which do not carry the Tg(SMN2*)1951Ahmb transgene (4.4 day survival); Tg(SMN2*)1951Ahmb homozygosity does not significantly enhance survival




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory