Analysis Tools
mortality/aging
| N |
• when mothers are maintained on N-carbamyl-L-glutamate (NCG) and L-citrulline (Cit) supplementation no prenatal lethality is seen
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• in supplemented adult mice removal of Cit reduces survival
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• pups from supplemented mothers die within 24-48 h of birth in the absence of intervention
• daily intraperitoneal injection of NCG and Cit followed by water based NCG and Cit supplementation allows most (85%) mice to survive and reproduce
• without Cit about 50% of pups die before weaning
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homeostasis/metabolism
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• increased glutamate levels in supplemented mice
• mice deprived of NCG and Cit supplementation display decreased levels of plasma arginine, citrulline, ornithine, proline and alanine and increased levels of glutamine, glutamate and lysine
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• mice deprived of NCG and Cit supplementation display decreased levels of plasma citrulline
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• all mice deprived of NCG and Cit supplementation develop severe hyperammonemia with symptoms appearing by 10 to 28 h of supplementation withdrawal
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growth/size/body
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• during the preweaning period in supplemented mice
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integument
sparse hair
(
J:184448
)
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• some supplemented adult mice appear to have less hair
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