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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Eif3ftm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:3847510
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Eif3ftm1(KOMP)Vlcg/Eif3ftm1(KOMP)Vlcg B6J.B6N-Eif3ftm1(KOMP)Vlcg MGI:6458760
ht2
Eif3ftm1(KOMP)Vlcg/Eif3f+ B6J.B6N-Eif3ftm1(KOMP)Vlcg MGI:6458761


Genotype
MGI:6458760
hm1
Allelic
Composition
Eif3ftm1(KOMP)Vlcg/Eif3ftm1(KOMP)Vlcg
Genetic
Background
B6J.B6N-Eif3ftm1(KOMP)Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif3ftm1(KOMP)Vlcg mutation (1 available); any Eif3f mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous mutants are recovered at birth following heterozygous intercrosses

reproductive system
• presence of empty decidua suggests that homozygous mutants die at an early post-implantation embryonic stage




Genotype
MGI:6458761
ht2
Allelic
Composition
Eif3ftm1(KOMP)Vlcg/Eif3f+
Genetic
Background
B6J.B6N-Eif3ftm1(KOMP)Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif3ftm1(KOMP)Vlcg mutation (1 available); any Eif3f mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than expected heterozygotes are born from heterozygous intercrosses (39% instead of 66%) and from crosses between heterozygous and wild-type mice (37% instead of 50%)
• crosses between male or female heterozygotes and wild-type mice revealed that heterozygous lethality is not associated with the production of dysfunctional spermatozoa or oocytes

growth/size/body
• at 4-6 months of age, heterozygotes show decreased lean body mass

muscle
• at 4 months of age, skeletal muscles of heterozygous mice show a reduction of muscle fiber size (tibialis, -21%; gastrocnemius, -24%; soleus, -26%; EDL, -17%)
• however, total fiber number and fiber type remain unaffected
• adult heterozygotes show reduced skeletal muscle mass; EDL, tibialis, quadriceps, gastrocnemius and soleus muscle mass is reduced by 14-18% relative to that in wild-type controls
• during hindlimb immobilization, heterozygotes show an exacerbated immobilization-induced skeletal muscle atrophy associated with reduced protein synthesis and reduced phosphorylation of S6K1 and S6 proteins relative to wild-type controls
• skeletal muscles of heterozygous mice show a deficiency in polysome content, a reduction in protein synthesis rate and an inhibition of the mechanistic target of rapamycin (MTOR) pathway

homeostasis/metabolism
• decreased skeletal muscle mass is associated with a reduction in the protein synthesis rate and an inhibition of the MTORC1 pathway

cellular
• decreased skeletal muscle mass is associated with a reduction in the protein synthesis rate and an inhibition of the MTORC1 pathway





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory