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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kat6atm1.1Glac
targeted mutation 1.1, Georges Lacaud
MGI:3847653
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kat6atm1.1Glac/Kat6atm1.1Glac involves: 129P2/OlaHsd * C57BL/6 MGI:3847660
ht2
 		Kat6atm1.1Glac/Kat6a+ involves: 129P2/OlaHsd * C57BL/6 MGI:3847659


Genotype
MGI:3847660
hm1
Allelic
Composition		 Kat6atm1.1Glac/Kat6atm1.1Glac
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat6atm1.1Glac mutation (0 available); any Kat6a mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:148955 )
• more than 40% of mice die within the first 6 months of life

hematopoietic system
decreased common myeloid progenitor cell number ( J:148955 )
• the numbers of common myeloid progenitors, megakaryocyte-erythroid progenitors, and granulocyte-macrophage progenitors are decreased in the fetal livers compared to in wild-type mice
decreased immature B cell number ( J:148955 )
• decreased frequency in the bone marrow and spleen
decreased pro-B cell number ( J:148955 )
• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
decreased pre-B cell number ( J:148955 )
• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
abnormal hematopoietic stem cell morphology ( J:148955 )
• fetal liver cells exhibit reduced repopulation efficiency compared with wild-type cells
• embryoid bodies exhibit impaired onset of hematopoeitic lineages compared to wild-type embryoid bodies
• proliferation of hematopoietic progenitors derived from embryoid bodies is reduced compared to cells derived from wild-type embryoid bodies
decreased hematopoietic stem cell number ( J:148955 )
• at E14.5, the frequency of Lin-/Sca-1+/c-Kit+ hematopoietic stem cells in the liver is decreased compared to in wild-type mice

growth/size/body
decreased body weight ( J:148955 )

immune system
decreased immature B cell number ( J:148955 )
• decreased frequency in the bone marrow and spleen
decreased pro-B cell number ( J:148955 )
• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
decreased pre-B cell number ( J:148955 )
• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice

endocrine/exocrine glands




Genotype
MGI:3847659
ht2
Allelic
Composition		 Kat6atm1.1Glac/Kat6a+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat6atm1.1Glac mutation (0 available); any Kat6a mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal hematopoietic stem cell morphology ( J:148955 )
• fetal liver cells exhibit reduced repopulation efficiency compared with wild-type cells
decreased hematopoietic stem cell number ( J:148955 )
• the numbers of erythroid and mixed lineage precursors are decreased compared to in wild-type mice
• fetal liver cells form fewer, smaller colonies than wild-type cells
• however, the number of myeloid lineage precursors is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory