mortality/aging
• more than 40% of mice die within the first 6 months of life
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hematopoietic system
• the numbers of common myeloid progenitors, megakaryocyte-erythroid progenitors, and granulocyte-macrophage progenitors are decreased in the fetal livers compared to in wild-type mice
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• decreased frequency in the bone marrow and spleen
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• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
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• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
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• fetal liver cells exhibit reduced repopulation efficiency compared with wild-type cells
• embryoid bodies exhibit impaired onset of hematopoeitic lineages compared to wild-type embryoid bodies
• proliferation of hematopoietic progenitors derived from embryoid bodies is reduced compared to cells derived from wild-type embryoid bodies
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• at E14.5, the frequency of Lin-/Sca-1+/c-Kit+ hematopoietic stem cells in the liver is decreased compared to in wild-type mice
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growth/size/body
immune system
• decreased frequency in the bone marrow and spleen
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• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
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• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
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endocrine/exocrine glands