About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kat6atm1.1Glac
targeted mutation 1.1, Georges Lacaud
MGI:3847653
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kat6atm1.1Glac/Kat6atm1.1Glac involves: 129P2/OlaHsd * C57BL/6 MGI:3847660
ht2
Kat6atm1.1Glac/Kat6a+ involves: 129P2/OlaHsd * C57BL/6 MGI:3847659


Genotype
MGI:3847660
hm1
Allelic
Composition
Kat6atm1.1Glac/Kat6atm1.1Glac
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat6atm1.1Glac mutation (0 available); any Kat6a mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• more than 40% of mice die within the first 6 months of life

hematopoietic system
• the numbers of common myeloid progenitors, megakaryocyte-erythroid progenitors, and granulocyte-macrophage progenitors are decreased in the fetal livers compared to in wild-type mice
• decreased frequency in the bone marrow and spleen
• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
• fetal liver cells exhibit reduced repopulation efficiency compared with wild-type cells
• embryoid bodies exhibit impaired onset of hematopoeitic lineages compared to wild-type embryoid bodies
• proliferation of hematopoietic progenitors derived from embryoid bodies is reduced compared to cells derived from wild-type embryoid bodies
• at E14.5, the frequency of Lin-/Sca-1+/c-Kit+ hematopoietic stem cells in the liver is decreased compared to in wild-type mice

growth/size/body

immune system
• decreased frequency in the bone marrow and spleen
• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice
• the frequencies of pro/pre-B cells in the bone marrow compared to in wild-type mice

endocrine/exocrine glands




Genotype
MGI:3847659
ht2
Allelic
Composition
Kat6atm1.1Glac/Kat6a+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat6atm1.1Glac mutation (0 available); any Kat6a mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• fetal liver cells exhibit reduced repopulation efficiency compared with wild-type cells
• the numbers of erythroid and mixed lineage precursors are decreased compared to in wild-type mice
• fetal liver cells form fewer, smaller colonies than wild-type cells
• however, the number of myeloid lineage precursors is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory